1876467-74-1

Basic information

• Product Name: BAY-1895344
• Synonyms: BAY-1895344;(R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridin-2-yl)morpholine
• CAS NO: 1876467-74-1
• Molecular Formula: C20H21N7O
• Molecular Weight: 375.42704
• Product Categories: API
• Mol File: 1876467-74-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 661.1±55.0 °C(Predicted)
• Appearance: /
• Density: 1.43±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 11.09±0.10(Predicted)
• CAS DataBase Reference: BAY-1895344(CAS DataBase Reference)
• NIST Chemistry Reference: BAY-1895344(1876467-74-1)
• EPA Substance Registry System: BAY-1895344(1876467-74-1)

Safety Data

• Hazardous Substances Data: 1876467-74-1(Hazardous Substances Data)

Usage

Description

Elimusertib, also known as BAY-1895344, is a selective ATR (ataxia-telangiectasia and Rad3 related protein) inhibitor. It is a pharmaceutical compound designed to target the ATR protein, which plays a crucial role in the DNA damage response and cell cycle regulation. By inhibiting ATR, Elimusertib can potentially disrupt the cell cycle and induce cell death in rapidly dividing cells, such as cancer cells.
Used in Oncology:
Elimusertib is used as an anticancer agent for the treatment of advanced hyperproliferative diseases, prophylaxis, solid tumors, and lymphomas. Its selective inhibition of the ATR protein makes it a promising therapeutic option for various cancer types, as it can target the underlying mechanisms that drive tumor growth and proliferation.
In addition to its direct anticancer effects, Elimusertib may also be used in combination with other cancer therapies to enhance their efficacy and overcome drug resistance. Its ability to target the DNA damage response and cell cycle regulation pathways makes it a valuable tool in the development of novel cancer treatment strategies.