18772-11-7

Basic information

• Product Name: 5-Nitro-2,1,3-benzoxadiazole
• Synonyms: 5-Nitro-2,1,3-benzoxadiazole;5-Nitrobenzofurazane;5-Nitrobenzo[c][1,2,5]oxadiazole
• CAS NO: 18772-11-7
• Molecular Formula: C₆H₃N₃O₃
• Molecular Weight: 0
• Mol File: 18772-11-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Nitro-2,1,3-benzoxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Nitro-2,1,3-benzoxadiazole(18772-11-7)
• EPA Substance Registry System: 5-Nitro-2,1,3-benzoxadiazole(18772-11-7)

Safety Data

• Hazardous Substances Data: 18772-11-7(Hazardous Substances Data)

Upstream product

• 18771-86-3 5-nitrobenzofuroxan 
• 97-02-9 2,4-Dinitroanilin 
• 293328-93-5 2-(tert-butyl-NNO-azoxy)-N,4-nitroaniline 
• 4096-88-2 1-azido-2,4-dinitrobenzene 
• 100450-03-1 2,5-dinitroazidobenzene 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 3702-88-3 5-nitrobenzofuroxane 

Downstream Products

• 19155-72-7 4-Methoxy-5-chlor-benzofurazan 
• 874-36-2 5-amino-benz[1,2,5]oxadiazole 
• 1380073-70-0 7-benzyl-6,8-dimethyl-7H-[1,2,5]oxadiazolo[3,4-e]isoindole 
• 1360067-56-6 7-benzyl-6-methyl-8-phenyl-7H-[1,2,5]oxadiazolo[3,4-e]isoindole 
• 1360067-53-3 7-benzyl-8-methyl-6-phenyl-7H-[1,2,5]oxadiazolo[3,4-e]isoindole 

Relevant articles and documents

Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase

Due to the oncogenic activity of cohesin protease, separase in human cancer cells, modulation of separase enzymatic activity could constitute a new therapeutic strategy for targeting resistant, separase-overexpressing aneuploid tumors. Herein, we report the synthesis, structural information, and structure–activity relationship (SAR) of separase inhibitors based on modification of the lead molecule 2,2-dimethyl-5-nitro-2H-benzimidazole-1,3-dioxide, named Sepin-1, (1) identified from a high-throughput-screen. Replacement of –NO2at C5 with other functional groups reduce the inhibitory activity in separase enzymatic assay. Substitution of the two methyl groups with other alkyl chains at the C2 moderately improves the effects on the inhibitory activity of those compounds. Modifications on 2H-benzimidazole-1,3-dioxide or the skeleton have variable effect on inhibition of separase enzymatic activity. Density-functional theory (DFT) calculations suggest there may be a correlation between the charges on the oxide moieties on these compounds and their activity in inhibiting separase enzyme.

Sulfur as a new low-cost and selective reducing agent for the transformation of benzofuroxans into benzofurazans

-

New approach to the synthesis of benzo[e][1,2,3,4]tetrazine 1,3-dioxides

A new approach to the synthesis of benzo[e][1,2,3,4]tetrazine 1,3-dioxides involves the treatment of N-nitroanilines containing an ortho-(tert-butyl-NNO-azoxy) group with phosphoric anhydride or phosphorus pentachloride. The reaction is supposed to procee