18778-96-6Relevant articles and documents
Total Synthesis of a Docosahexaenoic Acid Prostanoid Using an Intramolecular Organocatalytic Michael Reaction of a Formyl-Enal Derivative
Bultel-Poncé, Valérie,Durand, Thierry,Galano, Jean-Marie,Guy, Alexandre,Oger, Camille,Revol-Cavalier, Johanna
, p. 7455 - 7459 (2020)
The total synthesis of a docosahexaenoic-acid-derived prostaglandin, 4,11-diepi-4-F4t-neuroprostane, featuring a complex lateral chain was achieved for the first time. A novel prostaglandin cyclopentane skeleton obtained via an intramolecular highly selective organocatalytic Michael sequence of a formyl-enal derivative allowed the desired and exclusive thermodynamic trans configuration of the lipidic lateral chains.
Synthesis of a simplified triazole analogue of pateamine A
Hemi Cumming,Brown, Sarah L.,Tao, Xu,Cuyamendous, Claire,Field, Jessica J.,Miller, John H.,Harvey, Joanne E.,Teesdale-Spittle, Paul H.
, p. 5117 - 5127 (2016/06/14)
Pateamine A is a naturally occurring metabolite extracted from the marine sponge Mycale hentscheli. It exhibits potent cytotoxicity towards cancer cell lines and has been shown to target protein translation initiation via inhibition of the function of euk
Stereoselective synthesis of epoxyisoprostanes: an organocatalytic and "pot-economy" approach
Weng, Jiang,Wang, Sheng,Huang, Lin-Jie,Luo, Zhang-Yi,Lu, Gui
supporting information, p. 10170 - 10173 (2015/06/22)
An efficient and direct synthetic route to epoxyisoprostane EC methyl ester has been accomplished in 8 steps (10% overall yield) from readily available starting materials using a series of asymmetric organocatalytic reactions and one-pot operations.
