187816-62-2

Basic information

• Product Name: 1-(3-hydroxybenzyl)piperidine-4-carboxylic acid tert-butyl ester
• CAS NO: 187816-62-2
• Molecular Weight: 291.39
• Mol File: 187816-62-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-hydroxybenzyl)piperidine-4-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-hydroxybenzyl)piperidine-4-carboxylic acid tert-butyl ester(187816-62-2)
• EPA Substance Registry System: 1-(3-hydroxybenzyl)piperidine-4-carboxylic acid tert-butyl ester(187816-62-2)

Safety Data

• Hazardous Substances Data: 187816-62-2(Hazardous Substances Data)

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 138007-24-6 4-tert-butyl piperidine-4-carboxylate 

Downstream Products

• 187816-63-3 1-[3-(3-aminopropoxy)benzyl]piperidine-4-carboxylic acid tert-butyl ester 
• 1026859-95-9 Acetic acid {3-[3-(4-azidocarbonyl-piperidin-1-ylmethyl)-phenoxy]-propylcarbamoyl}-methyl ester 
• 187817-07-8 1-{3-[3-(2-Acetoxy-acetylamino)-propoxy]-benzyl}-piperidine-4-carboxylic acid tert-butyl ester 
• 187816-76-8 {3-[3-(4-isocyanatopiperidine-1-ylmethyl)phenoxy]propylcarbamoyl}methyl acetate 
• 187816-64-4 1-{3-[3-(2-acetoxyacetylamino)propoxy]benzyl}piperidine-4-carboxylic acid 
• 187817-06-7 1-{3-[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propoxy]-benzyl}-piperidine-4-carboxylic acid tert-butyl ester 

Relevant articles and documents

Synthesis and biological evaluation of a new reversely linked type of dual histamine H2 and gastrin receptor antagonist

In an attempt to improve the low oral absorbability of previously reported dual histamine H2 and gastrin receptor antagonists, compounds of a different type were synthesized and evaluated for biological activity. These new compounds bear a histamine H2 receptor antagonist (H2A) pharmacophore moiety attached to a gastrin receptor antagonist (GA) pharmacophore moiety in a reversed manner, namely the head-to-head manner, different from the previously reported head-to-tail manner. These new hybrid compounds were classified into three types: type 1, the regular amide type bearing a roxatidine moiety; type II, the reversed amide type bearing a roxatidine moiety: and type III, hybrid compounds bearing a famotidine moiety directly connected to a GA moiety without a spacer. Among them, only (R)-1-[3-(N'- {4-[2-(N-aminosulfonylamidino)ethylthiomethyl]thiazol-2- yl}guanidinomethyl)phenyl]-3(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4- benzodiazepin-3-yl)urea (42), belonging to type III, shorted a weak but distinct histamine H2 receptor-antagonistic activity as well as a modest gastrin receptor-antagonistic activity. Of most importance was the finding that this compound showed a weak but clearly improved in vivo oral antigastric acid secretory activity as a result of the structural changes, including the decreased molecular weight.