1879-77-2 Usage
Description
Doxibetasol, also known as Betamethasone Valerate EP Impurity B, is a derivative of the glucocorticoid Betamethasone (B327000). It is characterized by its anti-inflammatory properties and is primarily associated with the pharmaceutical industry due to its potential applications in various medical treatments.
Uses
Used in Pharmaceutical Industry:
Doxibetasol is used as an impurity in the production of Betamethasone, a glucocorticoid with potent anti-inflammatory and immunosuppressive properties. It is utilized for the treatment of various inflammatory conditions, such as skin disorders, allergies, and asthma. The presence of doxibetasol in Betamethasone formulations may affect the overall efficacy and safety profile of the medication, making it an important consideration in the development and quality control of glucocorticoid-based therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 1879-77-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,7 and 9 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1879-77:
(6*1)+(5*8)+(4*7)+(3*9)+(2*7)+(1*7)=122
122 % 10 = 2
So 1879-77-2 is a valid CAS Registry Number.
InChI:InChI=1/C22H29FO4/c1-12-9-17-16-6-5-14-10-15(25)7-8-19(14,3)21(16,23)18(26)11-20(17,4)22(12,27)13(2)24/h7-8,10,12,16-18,26-27H,5-6,9,11H2,1-4H3/t12-,16-,17-,18-,19-,20-,21-,22-/m0/s1
1879-77-2Relevant articles and documents
Reducing dehalogenating method of organic halogenated compound
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Paragraph 0099; 0100; 0102; 0124; 0129; 0130, (2019/02/10)
The invention discloses a reducing dehalogenating method of an organic halogenated compound. The reducing dehalogenating method comprises: mixing an organic halogenated compound R-X, a non-noble metalpromoter, a sulfide and an alkali, and carrying out a reducing dehalogenating reaction to obtain a reducing product R-H, wherein R is at least one selected from alkyl and aryl, and X is at least oneselected from iodine, bromine and chlorine. According to the present invention, the types and the ratio (especially the specific type of the promoter) of various raw materials used in the reducing dehalogenating reaction, the corresponding reaction conditions and the like are researched and improved, such that the problems of use of highly-toxic or expensive reagent, poor tolerance of the group, narrow application range of the substrate and the like in the prior art can be effectively solved.
16-Methyl-9α-halo steroid esters, ethers and preparation thereof
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, (2008/06/13)
New 16-methyl-9α-halo corticosteroid esters and ethers having high topical anti-inflammatory potency and low systemic activity and the manner in which they can be produced are described.