187996-52-7Relevant articles and documents
A General Strategy for the Preparation of Thalidomide-Conjugate Linkers
Papatzimas, James W.,Gorobets, Evgueni,Brownsey, Duncan K.,Maity, Ranjan,Bahlis, Nizar J.,Derksen, Darren J.
, p. 2881 - 2885 (2017/10/07)
The synthesis of small-molecule linkers for installation of thalidomide-based conjugates is described. Linker properties have been recognized as vital to conjugate success in drug discovery and delivery systems. These small-molecule tethers act as linkages between molecules, can also aid in cell permeability, and act as solubilizing agents. This work shows our progress in synthesizing conjugates with a variety of linker characteristics. The adaptability and manipulation of these and other linkers holds potential in improving synthetic control of chemical connectivities toward therapeutic development.
Effect of conformation of N-acyl carnosine and carcinine topochemical analogs on their antioxidant properties
Rozhkova,Ogrel',Grigor'ev,Nebol'sin,Zheltukhina,Evstigneeva
, p. 732 - 738 (2007/10/03)
To elucidate the influence of the nature of N-acyl substituent on antioxidant properties of carcinine analogs, the corresponding histamine derivatives were synthesized. Antioxidant activity of the compounds prepared was investigated in the Fe2+
