187998-44-3

Basic information

• Product Name: 1-(4-BROMO-PHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
• Synonyms: 1-(4-Bromo-phenyl)-5-methyl-1H-pyrazole-4-
• CAS NO: 187998-44-3
• Molecular Formula: C₁₁H₉BrN₂O₂
• Molecular Weight: 281.12
• Mol File: 187998-44-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 422.4°C at 760 mmHg
• Flash Point: 209.3°C
• Appearance: /
• Density: 1.61g/cm³
• Vapor Pressure: 6.86E-08mmHg at 25°C
• Refractive Index: 1.657
• CAS DataBase Reference: 1-(4-BROMO-PHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMO-PHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID(187998-44-3)
• EPA Substance Registry System: 1-(4-BROMO-PHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID(187998-44-3)

Safety Data

• Hazardous Substances Data: 187998-44-3(Hazardous Substances Data)

Usage

General Description

1-(4-Bromo-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid is a chemical compound with the molecular formula C11H8BrN3O2. It is a pyrazole derivative with a carboxylic acid functional group and a bromo-phenyl substituent. 1-(4-BROMO-PHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID is used in organic synthesis and medicinal chemistry as a building block for the preparation of various bioactive molecules. It has potential applications in the development of new pharmaceuticals and agrochemicals. Additionally, it may also be used as a research tool for studying the structure-activity relationships of pyrazole-containing compounds.

InChI:InChI=1/C11H9BrN2O2/c1-7-10(11(15)16)6-13-14(7)9-4-2-8(12)3-5-9/h2-6H,1H3,(H,15,16)

Upstream product

• 187998-45-4 ethyl 1-(4-bromophenyl)-5-methyl-1H-pyrazole-4-carboxylate 

Downstream Products

• 959578-65-5 C₁₁H₈BrClN₂O 
• 1227958-63-5 1-(4-bromophenyl)-5-methyl-1H-pyrazole 
• 288250-28-2 1-(4-bromophenyl)-N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide 
• 288250-67-9 1-(4-bromophenyl)-N-[3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide 

Relevant articles and documents

Functionalized 4-aminoquinolines by rearrangement of pyrazole N-heterocyclic carbenes

(Figure Presented) Thermal decarboxylation of 1-phenyl pyrazolium-3- carboxylates from the mesomeric betaine class of substances leads to pyrazole-N-heterocyclic carbenes, which immediately rearrange to multiply substituted 4-aminoquinolines (see scheme). These species are of interest for the synthesis of heterocycles and pharmacologically active compounds.

AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.