188016-53-7 Usage
General Description
N-BUTYLOXYCARBONYL-DAP-OH is a chemical compound with the molecular formula C13H21NO5. It is a derivative of the amino acid diaminopimelic acid (DAP) and is often used in peptide synthesis as a protective group for the amine functional group. The "N-BUTYLOXYCARBONYL" or "BOC" group serves as a temporary protecting group, which can be removed under mild conditions to expose the amine for further functionalization. N-BUTYLOXYCARBONYL-DAP-OH plays a key role in the production of complex peptides and is widely used in the pharmaceutical and biotechnology industries.
Check Digit Verification of cas no
The CAS Registry Mumber 188016-53-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,8,0,1 and 6 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 188016-53:
(8*1)+(7*8)+(6*8)+(5*0)+(4*1)+(3*6)+(2*5)+(1*3)=147
147 % 10 = 7
So 188016-53-7 is a valid CAS Registry Number.
188016-53-7Relevant articles and documents
The enantiospecific synthesis of an isoxazoline. A RGD mimic platelet GPIIb/IIIa antagonist
Zhang, Lin-Hua,Chung,Costello,Valvis,Ma,Kauffman,Ward
, p. 2466 - 2470 (2007/10/03)
A convergent, large-scale, chiral synthesis of isoxazoline 1 has been achieved in 37% overall yield and > 99.6% optical purity, starting from L-asparagine and 4-cyanobenzaldehyde. Hofmann reaction of N(α)-n-Boc-L-asparagine with iodosobenzene diacetate provides optically pure N(α)-n-Boc-L-α,β-diaminopropionic acid (8) in 75% yield. A process of lipase resolution-base catalyzed epimerization gives the single enantiomer 5. Reaction of acid 5 with amine 9 in the presence of thionyl chloride forms the framework of 1. A Pinner reaction of intermediate 4 in methyl acetate or anisole, followed by an amidination with ammonium acetate, gives optically pure product 1.
