18804-82-5

Basic information

• Product Name: 1-Butanamine, 4-methylbenzenesulfonate
• CAS NO: 18804-82-5
• Molecular Formula: C7H8O3S.C4H11N
• Molecular Weight: 245.343
• Mol File: 18804-82-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-Butanamine, 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Butanamine, 4-methylbenzenesulfonate(18804-82-5)
• EPA Substance Registry System: 1-Butanamine, 4-methylbenzenesulfonate(18804-82-5)

Safety Data

• Hazardous Substances Data: 18804-82-5(Hazardous Substances Data)

Usage

Appearance

White to off-white solid

Solubility

Soluble in polar solvents such as water and acetone

Uses

a. Catalyst or reagent in organic synthesis
b. Synthesis of pharmaceuticals, agrochemicals, and other fine chemicals
c. Drying agent or dehydrating agent in organic synthesis
d. Catalyst in esterification, etherification, and hydrolysis reactions
e. Reagent in the synthesis of polymers and plastics

Properties

a. Strong acid
b. Ability to facilitate various chemical reactions

Upstream product

• 109-65-9 1-bromo-butane 
• 104-15-4 toluene-4-sulfonic acid 
• 109-73-9 N-butylamine 
• 101709-22-2 Butyl-phosphorimidic acid triethyl ester 
• 20465-03-6 diethyl N-butylphosphoramidate 
• 85231-91-0 C₁₃H₂₈NO₅P 

Downstream Products

• 1907-65-9 N-butyl-4-toluenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

One-Pot synthesis of sulfonamides from primary and secondary amine derived sulfonate salts using cyanuric chloride

A convenient, mild and efficient one-pot synthesis of new sulfonamides is described. The reaction of primary or secondary amine derived sulfonate salts in the presence of cyanuric chloride, triethylamine as base, and anhydrous acetonitrile as solvent at room temperature gives the corresponding sulfonamides in good to excellent yields. Georg Thieme Verlag Stuttgart.

An optimized version of Gabriel-type nucleophilic amination

N-Alkylation of primary alkyl bromides with diethyl N-sodio-N-(t- butoxycarbonyl)phosphoramidate 1 carried out in boiling acetonitrile in the presence of 10mol% of tetrabutylammonium bromide as catalyst leads to the corresponding N-alkyl derivatives 2a-I. Deprotection of 2 by refluxing with p-toluenesulfonic acid in ethanol-affords ammonium tosylates 3a-I in reasonable yields.

Novel organophosphorus reagents for the synthesis of amines

New organophosphorus equivalents of a2 type N-protected amine synthons are presented.