188056-01-1

Basic information

• Product Name: (S)-2-tert-Butoxycarbonylamino-3-[4-(1-isopropyl-2-methyl-propoxycarbonyloxy)-phenyl]-propionic acid
• CAS NO: 188056-01-1
• Molecular Weight: 423.507
• Mol File: 188056-01-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-tert-Butoxycarbonylamino-3-[4-(1-isopropyl-2-methyl-propoxycarbonyloxy)-phenyl]-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-tert-Butoxycarbonylamino-3-[4-(1-isopropyl-2-methyl-propoxycarbonyloxy)-phenyl]-propionic acid(188056-01-1)
• EPA Substance Registry System: (S)-2-tert-Butoxycarbonylamino-3-[4-(1-isopropyl-2-methyl-propoxycarbonyloxy)-phenyl]-propionic acid(188056-01-1)

Safety Data

• Hazardous Substances Data: 188056-01-1(Hazardous Substances Data)

Upstream product

• 19391-35-6 N-tert-butoxycarbonyl-L-tyrosine benzyl ester 
• 3978-80-1 Boc-Tyr-OH 
• 30250-57-8 2,4-dimethyl-3-pentyl chloroformate 
• 173254-36-9 (S)-2-tert-Butoxycarbonylamino-3-[4-(1-isopropyl-2-methyl-propoxycarbonyloxy)-phenyl]-propionic acid benzyl ester 

Relevant articles and documents

The 2,4-dimethylpent-3-yloxycarbonyl (Doc) group as a new, nucleophile-resistant protecting group for tyrosine in solid phase peptide synthesis

The 2,4-dimethylpent-3-yloxycarbonyl (Doc) group is presented as a new protecting group for tyrosine. The Doc group is 1000-fold more stable towards the nucleophile piperidine than the commonly used 2-bromobenzyloxycarbonyl (2-BrZ) group is, and it is completely cleaved by hydrogen fluoride.