1882-86-6Relevant articles and documents
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Magerlein et al.
, p. 1709,1713 (1955)
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Total Synthesis of ( +/-)-Cortisone. Double-Hydroxylation Reaction for Corticoid Synthesis
Horiguchi, Yoshiaki,Nakamura, Eiichi,Kuwajima, Isao
, p. 6257 - 6265 (2007/10/02)
Total syntheses of (+/-)-cortisone and (+/-)-adrenosterone have been achieved in 18 steps with the aid of metal-assisted new synthetic sequences in particular, ene reaction and homoenolate chemistry.A novel double-hydroxylation reaction of enol silyl ethers leading to a single step construction of the dihydroxyacetone side chain in corticoids has been developed and applied to the synthesis of cortisone, cortexolone, and 16α-methylcortexolone.