188292-96-8Relevant articles and documents
Synthesis and biological activity of 5-[(2,5-dihydroxybenzyl)amino]salicylic acid analogs as inhibitors of EGF receptor-associated protein tyrosine kinase
Liu, Tianming,Shirai, Ryuichi,Matsui, Takashi,Umezawa, Kazuo,Iwasaki, Shigeo
, p. 365 - 368 (2007/10/03)
The synthesis and biological activity of a series of 5-[(2,5-dihydroxybenzyl)amino]salicylic acid derivatives (3-6) as analogs of the active partial structure (2) of the potent EGF-R tyrosine kinase inhibitor lavendustin A (1) are described. Analogs with an electron-withdrawing group in place of the carboxyl group of 2 showed activity. The N-hexylsalicylamide analog 6b (IC50 = 0.9 μM) was about four times more potent than 2.