188527-03-9

Basic information

• Product Name: tert-butyl 4-(4-bromophenylthio)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(4-bromophenylthio)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-[(4-broMophenyl)thio]-, 1,1-diMethylethyl ester;tert-butyl 4-(4-bromophenyl)sulfanylpiperidine-1-carboxylate
• CAS NO: 188527-03-9
• Molecular Formula: C₁₆H₂₂BrNO₂S
• Molecular Weight: 372.32038
• Mol File: 188527-03-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 4-(4-bromophenylthio)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(4-bromophenylthio)piperidine-1-carboxylate(188527-03-9)
• EPA Substance Registry System: tert-butyl 4-(4-bromophenylthio)piperidine-1-carboxylate(188527-03-9)

Safety Data

• Hazardous Substances Data: 188527-03-9(Hazardous Substances Data)

Usage

Description

Tert-butyl 4-(4-bromophenylthio)piperidine-1-carboxylate is a chemical compound with a molecular formula C17H24BrNO2S. It is an ester derivative of piperidine, containing a tert-butyl group and a 4-(4-bromophenylthio) substituent. tert-butyl 4-(4-bromophenylthio)piperidine-1-carboxylate has potential applications in the field of organic chemistry, pharmaceuticals, and agrochemicals.

Uses

Used in Organic Chemistry:
Tert-butyl 4-(4-bromophenylthio)piperidine-1-carboxylate is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure allows for versatile chemical reactions, making it a valuable building block in organic synthesis.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, tert-butyl 4-(4-bromophenylthio)piperidine-1-carboxylate is used as a precursor in the synthesis of bioactive molecules and drug candidates. Its presence in the molecule can impart specific pharmacological properties, contributing to the development of new therapeutic agents.
Used in Agrochemicals:
Tert-butyl 4-(4-bromophenylthio)piperidine-1-carboxylate is also utilized in the agrochemical sector as an intermediate for the synthesis of agrochemical products. Its chemical properties can be harnessed to create compounds with pesticidal or herbicidal activities, contributing to crop protection and yield enhancement.

Upstream product

• 106-53-6 para-bromobenzenethiol 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 24424-99-5 di-tert-butyl dicarbonate 
• 911410-37-2 1-(4-hydroxypiperidin-1-yl)-2,2-dimethylpropan-1-one 

Downstream Products

• 226398-62-5 4-(4-bromobenzenesulfonyl)piperidine-1-carboxylic acid tert-butyl ester 
• 285995-01-9 4-(4-bromophenylsulfonyl)piperidine 
• 285995-02-0 N-(2,4-difluorophenethyl) 4-(4-bromophenylsulfonyl)piperidine 
• 285994-62-9 4-(4-cyanophenylsulphonyl)-1-[2-(2,4-difluorophenyl)ethyl]piperidine 
• 797750-44-8 4-(4-cyanobenzenesulfonyl)piperidine-1-carboxylic acid tert-butyl ester 
• 1450723-99-5 C₁₂H₁₄N₂O₂S 
• 1450724-00-1 4-(1-acetylpiperidine-4-sulfonyl)benzonitrile 
• 1450724-01-2 C₁₅H₁₈N₂O₃S 
• 1450724-04-5 C₁₅H₁₈N₂O₃S 
• 1450724-05-6 4-[1-(tetrahydropyran-4-yl)piperidine-4-sulfonyl]benzonitrile 
• 1450724-02-3 C₁₃H₁₆N₂O₂S 
• 1450724-03-4 C₁₅H₂₀N₂O₂S 
• 1450723-87-1 C₁₃H₂₀N₂O₂S 
• 1450723-88-2 C₁₅H₂₄N₂O₂S 

Relevant articles and documents

Synthesis and Characterization of N-(4-(Piperidin-4-ylsulfonyl) phenyl)5-vinylpyrimidin-2-amine

Target product N-(4-(piperidin-4-ylsulfonyl)phenyl)5-vinylpyrimidin-2- amine (13) was synthesized using 6-oxopyran-3-carbaldehyde (M1) and 4-hydroxypiperidine (M2) as starting materials by a series of nucleophilic substitution and oxidation. Different aci

Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors containing 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas were identified using structure-based design techniques. The new compounds displayed improved aqueous solubilities, determined using a high-throughput solubility assessment, relative to previously disclosed urea and amide-containing NAMPT inhibitors. An optimized 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived compound exhibited potent anti-NAMPT activity (18; BC NAMPT IC50 = 11 nM; PC-3 antiproliferative IC50 = 36 nM), satisfactory mouse PK properties, and was efficacious in a PC-3 mouse xenograft model. The crystal structure of another optimized compound (29; NAMPT IC50 = 10 nM; A2780 antiproliferative IC50 = 7 nM) in complex with the NAMPT protein was also determined.

THIAZOLE INHIBITORS TARGETING RESISTANT AND KINASE MUTATIONS

A compound is provided, having the general structure (A): wherein A is an aryl or heteroaryl group, Y is a hydrophobic linking moiety, and L is a substitutent. The compound (A) can be used for treatment of various angiogenic-associated or hematologic disorders, such as myeloproliferative disorders in patients who do not respond to kinase-inhibition therapy that comprises administering currently used medications.