188608-11-9

Basic information

• Product Name: Phosphinous acid, [3-[bis(trimethylsilyl)amino]phenyl]phenyl-, methyl ester
• CAS NO: 188608-11-9
• Molecular Formula: C19H30NOPSi2
• Molecular Weight: 375.598
• Mol File: 188608-11-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Phosphinous acid, [3-[bis(trimethylsilyl)amino]phenyl]phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphinous acid, [3-[bis(trimethylsilyl)amino]phenyl]phenyl-, methyl ester(188608-11-9)
• EPA Substance Registry System: Phosphinous acid, [3-[bis(trimethylsilyl)amino]phenyl]phenyl-, methyl ester(188608-11-9)

Safety Data

• Hazardous Substances Data: 188608-11-9(Hazardous Substances Data)

Upstream product

• 4073-30-7 (N,N-dimethyl)-(chloro-phenyl-phosphino)-amine 
• 174484-84-5 3-[Bis(trimethylsilyl)amino]-phenylmagnesium chloride 
• 4073-31-8 (diethylamino)phenylchlorophosphine 

Downstream Products

• 188608-15-3 [2-(diphenylphosphino)ethyl][3-(N,N-bis(trimethylsilyl)amino)phenyl]phenylphosphine 
• 188608-13-1 3-Phenylphosphanyl-phenylamine 
• 188608-12-0 [3-(1,1,1,3,3,3-Hexamethyl-disilazan-2-yl)-phenyl]-phenyl-phosphane 

Relevant articles and documents

Water Soluble Cationic Phosphine Ligands Containing m-Guanidinium Phenyl Moieties. Syntheses and Applications in Aqueous Heck Type Reactions

Cationic phosphine ligands containing m-guanidinium phenyl substituents {Ph3-nP[C6H4-m-NHC(NH2)(NMe 2)]n}n+ nCl- (n = 1-3) (17a-c) have been obtained by addition of dimethylcyanamide to the amino groups of tertiary (m-aminophenyl)phosphines in acidic medium. The tertiary (m-aminophenyl)phosphines Ph3-nP(C6H4-m-NH2)n (4a-c) were prepared by reaction of (3-[N,N-bis(trimethylsilyl)amino]phenyl)magnesium chloride (1) with chlorophosphines Ph3-nPCln followed by deprotection of the bis(trimethylsilyl)amino groups with methanol. Using a similar protected group synthesis as above, the secondary (m-aminophenyl)phosphine Ph(H)PC6H4-m-NH2 (7) could be prepared as well. It may be employed as a building block for the syntheses of chiral bidentate phosphine ligands (11, 14, and 15) bearing m-aminophenyl substituents. The guanidinium phosphines 17b and 17c are readily soluble in water. A comparative study of 17b and 17c, the aryl alkyl guanidinium phosphines 18 and 19, and TPPTS (P(C6H4-m-SO3Na)3) in the aqueous phase palladium-catalyzed C-C coupling reaction between p-iodobenzoate and (trifluoroacetyl)propar-gylamine shows 17b to be of surmounting activity.