18863-72-4Relevant articles and documents
A New Secondary Metabolite from Alternaria Alternata: Structure Elucidation and Total Synthesis of Altenuic Acid IV
Kohler, Dominik,Podlech, Joachim
, p. 1748 - 1753 (2019)
A putative intermediate in the biosynthesis of altenuic acids I–III was isolated from Alternaria alternata in the 1950ies and a sample survived over the decades. This resorcylic lactone named altenuic acid IV is a composite of a resorcylic and a muconic a
A 4, 5 - dihydroxy -2 - methyl benzoic acid
-
Paragraph 0051-0053, (2017/05/03)
The invention discloses a preparation method of 4,5-dihydroxyl-2-methyl benzoic acid and belongs to the fields of fine chemical engineering and medicine intermediates. The preparation method of 4,5-dihydroxyl-2-methyl benzoic acid comprises the following steps: preparing an intermediate III or V by taking 4-methylbenze-1,2-diphenol as a raw material, then preparing an intermediate IV by virtue of the intermediate III or V, then transforming the intermediate IV into an intermediate II, and finally preparing 4,5-dihydroxyl-2-methyl benzoic acid by virtue of the intermediate II. The preparation method of 4,5-dihydroxyl-2-methyl benzoic acid has the advantage that the problems that raw materials are difficult to acquire, byproducts are many, yield is low, cost is high, steps are miscellaneous, safety can not be guaranteed and serious pollution is produced in the prior art are overcome.
Benzodioxoles: Novel cannabinoid-1 receptor inverse agonists for the treatment of obesity
Alig, Leo,Alsenz, Jochem,Andjelkovic, Mirjana,Bendels, Stefanie,Bénardeau, Agnès,Bleicher, Konrad,Bourson, Anne,David-Pierson, Pascale,Guba, Wolfgang,Hildbrand, Stefan,Kube, Dagmar,Lübbers, Thomas,Mayweg, Alexander V.,Narquizian, Robert,Neidhart, Werner,Nettekoven, Matthias,Plancher, Jean-Marc,Rocha, Cynthia,Rogers-Evans, Mark,R?ver, Stephan,Schneider, Gisbert,Taylor, Sven,Waldmeier, Pius
, p. 2115 - 2127 (2008/12/22)
The application of the evolutionary fragment-based de novo design tool TOPology Assigning System (TOPAS), starting from a known CB1R (CB-1 receptor) ligand, followed by further refinement principles, including pharmacophore compliance, chemical tractabili