188635-30-5 Usage
Description
(3R)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-butanoic Acid Ethyl Ester is a complex organic compound characterized by its colorless oil appearance. It features a unique structure with a chiral center at the 3R position, a dimethylsilyl ether group, and an ester functional group. This molecule is of interest due to its potential applications in various fields, particularly in the synthesis of complex molecules for pharmaceutical purposes.
Uses
Used in Pharmaceutical Synthesis:
(3R)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-butanoic Acid Ethyl Ester is used as an intermediate in the synthetic preparation of 35-deoxy amphotericin B Me ester. (3R)-4-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-3-hydroxy-butanoic Acid Ethyl Ester serves as a key building block in the development of novel molecular editing strategies, which have significant implications in the field of medicine, particularly in the treatment of various diseases and conditions.
Used in Chemical Research:
As a colorless oil with unique structural features, (3R)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-butanoic Acid Ethyl Ester can be utilized in chemical research to explore its reactivity, stability, and potential applications in the synthesis of other complex organic molecules. This may lead to the discovery of new compounds with diverse applications in various industries.
Used in Material Science:
The unique properties of (3R)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-butanoic Acid Ethyl Ester, such as its colorless oil appearance and structural characteristics, may make it a candidate for use in the development of new materials with specific properties. These materials could have applications in various industries, including electronics, coatings, and adhesives.
Check Digit Verification of cas no
The CAS Registry Mumber 188635-30-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,8,6,3 and 5 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 188635-30:
(8*1)+(7*8)+(6*8)+(5*6)+(4*3)+(3*5)+(2*3)+(1*0)=175
175 % 10 = 5
So 188635-30-5 is a valid CAS Registry Number.
188635-30-5Relevant articles and documents
Synthesis and biophysical studies on 35-Deoxy amphotericin b methyl ester
Szpilman, Alex M.,Cereghetti, Damiano M.,Manthorpe, Jeffrey M.,Wurtz, Nicholas R.,Carreira, Erick M.
supporting information; experimental part, p. 7117 - 7128 (2010/03/05)
The use of molecular editing in the elucidation of the mechanism of action of amphotericin B is presented. A modular strategy for the synthesis of amphotericin B and its designed analogues is developed, which relies on an efficient gram-scale synthesis of various subunits of amphotericin B. A novel method for the coupling of the mycosa-mine to the aglycone was identified. The implementation of the approach has enabled the preparation of 35-deoxy amphotericin B methyl ester. Investigation of the antifungal activity and efflux-inducing ability of this amphotericin B congener provided new clues to the role of the 35-hydroxy group and is consistent with the involvement of double barrel ion channels in causing electrolyte efflux. 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
Synthesis of (+)-2,8-dihydroxyethyl-1,4,7,10-tetraoxaspiro[5.5]undecane from (R)-4-hydroxymethyl-2,2-dimethyl-1,3-dioxane
Sauret-Cladiere, Sandrine,Jeminet, Georges
, p. 417 - 423 (2007/10/03)
Selective transformations of diethyl (R)-malate afforded (R)-4-hydroxymethyl 2,2-dimethyl-1,3-dioxane 7 in reasonable yield. Subsequent synthesis of (2S,6R,8S)-2,8-di hydroxyethyl-1,4,7,10-tetraoxaspiro[5.5]undecane 11 was achieved using precursor 7.
