188635-62-3

Basic information

• Product Name: (R)-4-Azido-3-(4-chloro-phenyl)-butyric acid
• Synonyms: (R)-4-Azido-3-(4-chloro-phenyl)-butyric acid
• CAS NO: 188635-62-3
• Molecular Weight: 239.661
• Mol File: 188635-62-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-4-Azido-3-(4-chloro-phenyl)-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-Azido-3-(4-chloro-phenyl)-butyric acid(188635-62-3)
• EPA Substance Registry System: (R)-4-Azido-3-(4-chloro-phenyl)-butyric acid(188635-62-3)

Safety Data

• Hazardous Substances Data: 188635-62-3(Hazardous Substances Data)

Upstream product

• 26717-54-4 β-(4-chlorophenyl)-γ-butyrolactone 
• 188635-61-2 (R)-3-(4-Chloro-phenyl)-4-iodo-butyric acid ethyl ester 
• 147224-51-9 β-(R)-(p-chlorophenyl)-γ-butyrolactone 
• 147224-53-1 (R)-ethyl 4-azido-3-(4-chlorophenyl)-1-butanoate 
• 152714-07-3 3-(4-chlorophenyl)cyclobutanone 
• 1073-67-2 4-vinylbenzyl chloride 

Downstream Products

• 63701-55-3 (R)-(-)-baclofen hydrochloride 

Relevant articles and documents

A chemoenzymatic strategy for the synthesis of enantiopure (R)-(-)-baclofen

A seven-step enantioselective synthesis of (R)-(-)-baclofen 1 is described. The strategy developed involved as a key step, a microbiologically mediated Baeyer Villiger oxidation of the prochiral 3-(4'-chlorobenzyl)-cyclobutanone 3 which led to the optically pure (R)-(-)-4 lactone. This was further transformed throughout chemospecific reactions into the target molecule (R)-(-)-1.