188640-67-7

Basic information

• Product Name: 4,4',4''-(1,3,5-Benzene-triyltri-2,1-ethynediyl)tris-L-phenylalanine> trimethyl ester
• CAS NO: 188640-67-7
• Molecular Weight: 982.14
• Mol File: 188640-67-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4,4',4''-(1,3,5-Benzene-triyltri-2,1-ethynediyl)tris-L-phenylalanine> trimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4',4''-(1,3,5-Benzene-triyltri-2,1-ethynediyl)tris-L-phenylalanine> trimethyl ester(188640-67-7)
• EPA Substance Registry System: 4,4',4''-(1,3,5-Benzene-triyltri-2,1-ethynediyl)tris-L-phenylalanine> trimethyl ester(188640-67-7)

Safety Data

• Hazardous Substances Data: 188640-67-7(Hazardous Substances Data)

Upstream product

• 7567-63-7 1,3,5-Triethynylbenzene 
• 210962-91-7 2-tert-Butoxycarbonylamino-3-(4-iodo-phenyl)-propionic acid methyl ester 

Relevant articles and documents

Alkyne bridged α-amino acids by palladium mediated coupling of alkynes with N-t-Boc-4-iodo-phenylalanine methyl ester

The Heck reaction of trimethylsilylacetylene with N-t-Boc-4-iodo-L-phenylalanine methyl ester gives N-t-Boc-4-ethynyl-L-phenylalanine methyl ester (2). Coupling of 2 with different alkynes yields alkyne bridged linear amino acid esters 3-5. Also tripodal and tetrapodal amino acid esters 10 and 11 were prepared by this approach. All compounds have been obtained in enantiomerically pure form. The protecting groups were removed by standard methods to yield the free amino acids as hydrochlorides.