188650-93-3Relevant articles and documents
Asymmetric synthesis of ibuprofen via diastereoselective alkylation of a homochiral N-acylbornanesultam
Oppolzer, Wolfgang,Rosset, Stephane,De Brabander, Jef
, p. 1539 - 1540 (1997)
A very short, 4 step synthesis of 2-(4-isobutylphenyl)propionic acid (ibuprofen) was achieved in 57% overall. yield, using a highly diastereoselective alkylation of the chiral enolate derived from N-(4-isobutylphenyl)acetyl bornanesultam as a key step.