18871-66-4 Usage
Description
1,1-Dimethoxy-N,N-dimethylethylamine is an organic compound with the chemical formula C6H15NO2. It is a clear yellow to brown liquid and is known for its reactivity in various chemical reactions, particularly as a one-carbon inserting synthon and a reagent for the synthesis of amides, diacylamines, and heterocycles.
Uses
Used in Pharmaceutical Industry:
1,1-Dimethoxy-N,N-dimethylethylamine is used as a one-carbon inserting synthon for the preparation of pyrimido[1,2-a][1,3,5]triazin-6-ones, which are important compounds in the development of new pharmaceuticals. Its ability to insert a carbon atom into a molecule makes it a valuable synthetic building block in the synthesis of various drug candidates.
Used in Chemical Synthesis:
1,1-Dimethoxy-N,N-dimethylethylamine is used as a reagent for the synthesis of amides, diacylamines, and heterocycles. Its versatility in chemical reactions allows it to be employed in the production of a wide range of chemical compounds, contributing to the development of new materials and products in various industries.
Used in Research and Development:
The Claisen type reaction of 1,1-Dimethoxy-N,N-dimethylethylamine using optically active trans-3-penten-2-ol as a substrate has been investigated. This research contributes to the understanding of the compound's reactivity and potential applications in the synthesis of complex organic molecules, which can be further explored for various industrial and pharmaceutical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 18871-66-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,8,7 and 1 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 18871-66:
(7*1)+(6*8)+(5*8)+(4*7)+(3*1)+(2*6)+(1*6)=144
144 % 10 = 4
So 18871-66-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H15NO2/c1-6(8-4,9-5)7(2)3/h1-5H3/p+1
18871-66-4Relevant articles and documents
Design, synthesis and anti-tumoractivity of novel amidine derivatives of doxifluridine
Feng, Ji Lu,Sun, Hai Ling,Geng, Dong Ping,Li, Ke
, p. 163 - 166 (2010)
A series of novel amidine derivatives of doxifluridine were synthesized using acid amide as the starting material, and their anti-tumor activity was evaluated in A549 cells. Compounds 10 and 11 demonstrated were more potent than 5-Fu, which was used as a positive control. Compound 10, which were found to be the most potent one with IC50 of 3.2 μmol/L, was 16 times more potent than 5-Fu with IC50 of 52 μM to the A549 cells. A new route was designed to synthesize 5′-deoxy-5-fluorocytidine. All compounds were characterized by 1H NMR, MS and X-ray spectras in detail.
Novel and efficient one-pot synthesis of N'-alkyl-N,N-dimethylacetamidines
Li, Zhe-Qi,Wang, Hui-Long
, p. 119 - 120 (2011)
An efficient method for the synthesis of N'-alkyl-N,N-dimethylacetamidine derivatives under mild conditions and in excellent yields involved reacting primary alkylamines with N,N-dimethylacetamide in the presence of LiCl as a catalyst and methanol as the acetalising reagent.
HETEROCYCLIC INDOLE DERIVATIVES AND MONO- OR DIAZAINDOLE DERIVATIVES
-
, (2008/06/13)
Indole derivatives and mono- or diazaindole derivatives represented by general formula (1), pharmaceutically acceptable acid-addition salts or base-addition salts thereof or hydrates of the same which have a COX-2 inhibitory activity and are useful as drugs such as anti-inflammatory agents, wherein Het represents an optionally substituted heterocycle; A1 and A2 independently represent each -CH=, etc.; A3 represents -CH2-, etc.; R1 represents 4-fluorophenyl, etc.; R2 represents alkyl; and n is 0, 1 or 2, provided that when A1 and A2 are both -CH=, then A3 is -CH2- or -SO2-.
