18888-57-8

Basic information

• Product Name: 1,2,4-trimethyl-5-nitro-1H-imidazole
• Synonyms: 1,2,4-Trimethyl-5-nitroimidazole; 1H-imidazole, 1,2,4-trimethyl-5-nitro-; Imidazole, 1,2,4-trimethyl-5-nitro-
• CAS NO: 18888-57-8
• Molecular Formula: C₆H₉N₃O₂
• Molecular Weight: 155.1546
• Mol File: 18888-57-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 316.2°C at 760 mmHg
• Flash Point: 145.1°C
• Density: 1.3g/cm³
• Vapor Pressure: 0.000771mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 1,2,4-trimethyl-5-nitro-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-trimethyl-5-nitro-1H-imidazole(18888-57-8)
• EPA Substance Registry System: 1,2,4-trimethyl-5-nitro-1H-imidazole(18888-57-8)

Safety Data

• Hazardous Substances Data: 18888-57-8(Hazardous Substances Data)

Usage

Appearance

Yellow crystalline solid

Usage

Synthesis of pharmaceuticals and agrochemicals

Properties

Antibacterial and antiprotozoal

Potential

Candidate for the development of new drugs

Structure

1H-imidazole ring with three methyl groups and a nitro group attached at different positions

Importance

Valuable compound in medicinal chemistry research

Safety concerns

Potential toxicity and environmental impacts

Handling and disposal

Proper protocols should be followed

Upstream product

• 49780-25-8 2,4-dimethyl-5-nitroimidazole 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 104575-30-6 1,2-dimethyl-4-(2-hydroxyethyl)-5-nitroimidazole pivalate 
• 104575-31-7 1,2-dimethyl-4-(2-hydroxyethyl)-5-nitroimidazole acetate 
• 104575-38-4 1,4-dimethyl-2-(2-hydroxyethyl)-5-nitroimidazole 
• 104575-27-1 1,2-dimethyl-4-(2-hydroxyethyl)-5-nitroimidazole 

Relevant articles and documents

1,2(1,4)-dimethyl-4(2)-(2-hydroxyethyl)-5-nitro-imidazole antiprotozoal agents with reduced mutagenicity

A group of 4-substituted-5-nitroimidazoles is described, having effective antiprotozoal activity with much less mutagenicity than is shown by known 5-nitroimidazoles.