188937-31-7

Basic information

• Product Name: 5-Pyrimidinecarboxylic acid, 4-chloro-2-[4-(trifluoromethyl)phenyl]-, ethyl ester
• CAS NO: 188937-31-7
• Molecular Formula: C14H10ClF3N2O2
• Molecular Weight: 330.694
• Mol File: 188937-31-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinecarboxylic acid, 4-chloro-2-[4-(trifluoromethyl)phenyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylic acid, 4-chloro-2-[4-(trifluoromethyl)phenyl]-, ethyl ester(188937-31-7)
• EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 4-chloro-2-[4-(trifluoromethyl)phenyl]-, ethyl ester(188937-31-7)

Safety Data

• Hazardous Substances Data: 188937-31-7(Hazardous Substances Data)

Upstream product

• 131472-28-1 4-trifluoromethylbenzamidine 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 64633-82-5 4-hydroxy-2-(4-trifluoromethyl-phenyl)-pyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 188937-34-0 4-hydrazino-2-(4-trifluoromethyl-phenyl)-pyrimidine-5-carboxylic acid ethyl ester 

Relevant articles and documents

Compounds

Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.

Novel inhibitors of AP-1 and NF-κB mediated gene expression: Structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)pyrimidine-5-carb oxylate

In an effort to identify novel inhibitors of AP-1 and NF-κB mediated transcriptional activation, several analogues of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)pyrimidine-5-carb oxylate (1) were synthesized and tested in two in vitro assays. The 2-(2'-thienyl) substituted compound (11) was identified as the most potent in this series. (C) 2000 Elsevier Science Ltd. All rights reserved.