188975-34-0Relevant articles and documents
New classes of antibacterial oxazolidinones with C-5, methylene O-linked heterocyclic side chains
Gravestock, Michael B.,Acton, David G.,Betts, Michael J.,Dennis, Michael,Hatter, Glenn,McGregor, Alexandra,Swain, Michael L.,Wilson, R. Geoffrey,Woods, Lisa,Wookey, Alan
, p. 4179 - 4186 (2007/10/03)
Exploration of the structure-activity relationships of the traditional C-5 acetamidomethyl side chain of the oxazolidonone antibacterials has yielded new, potent series of compounds of which the first examples, the O-linked iosoxazoles are described in detail, leading to the selection of the pre-clinical candidate AZD2563.