1890-04-6Relevant articles and documents
5,6,7,-trinor-4,8-inter-m-phenylene 2-nor PGI2 derivatives and anti-ulcer, anti-thrombotic and anti-hypertensive pharmaceutical compositions containing them
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, (2008/06/13)
Pharmaceutically useful compounds are 5,6,7-trinor-4,8-inter-m-phenylene PGI2 derivatives such as 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-16,16-dimethyl PGI2, 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(S)-methyl PGI2, 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(R)-methyl PGI2, 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-16,16-dimethyl-ω-homo PGI2, 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(S)-methyl-ω-homo PGI2, 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(R)-methyl-ω-homo PGI2, 5,6, 7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16,16-dimethyl-16-p ropoxy PGI2, 5,6,7-trinor-4,8-inter-m-phenylene-2,18,19,20-tetranor-16,16-dimethyl-17-etho xy PGI2, 5,6,7-trinor-4,8-inter-m-phenylene-2,18,19,20-tetranor-16,16-dimethyl-17-prop oxy PGI2, 5,6,7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16-phenoxy PGI2 and methyl esters thereof. 5,6,7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16,16-dimethyl-16 -phenoxy PGI2 or its methyl ester, 5,6,7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16-methyl-16-phenox y PGI2 or its methyl ester. They are useful in treatment of ulcers, thrombii and hypertension for example.