189000-91-7 Usage
Description
2,2'-Diamino-4,4'-bipyridine, also known as bipyridine diamine, is an organic compound with a bipyridine structure and two amino groups attached to the 2,2' positions. It is a versatile building block in the synthesis of various chemical compounds and has potential applications in different industries due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
2,2'-Diamino-4,4'-bipyridine is used as a key intermediate in the design and synthesis of a new series of c-Jun N-terminal kinase-3 (JNK3) inhibitors. These inhibitors play a crucial role in regulating cellular processes such as cell growth, differentiation, and apoptosis, making them potential therapeutic targets for various diseases, including cancer and neurodegenerative disorders.
Used in Chemical Synthesis:
2,2'-Diamino-4,4'-bipyridine serves as a valuable building block in the synthesis of various organic compounds, including ligands, coordination complexes, and organic dyes. Its unique structure and functional groups allow for the formation of diverse chemical entities with potential applications in different fields, such as catalysis, sensors, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 189000-91-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,0,0 and 0 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 189000-91:
(8*1)+(7*8)+(6*9)+(5*0)+(4*0)+(3*0)+(2*9)+(1*1)=137
137 % 10 = 7
So 189000-91-7 is a valid CAS Registry Number.
189000-91-7Relevant articles and documents
Synthesis of Cyclo-2,2′:4′,4″:2″,2?:4?,4″″: 2″″,2″″′:4″″′,4-sexipyridine
Kelly, T. Ross,Lee, Yean-Jang,Mears, Richard J.
, p. 2774 - 2781 (1997)
Preparation of the title compound (2) by use of Stille couplings and a Kroehnke pyridine synthesis is described. By application of the Stille coupling reaction, preparation and functionalization of quater- and quinquepyridines 26, 27, and 28 were achieved. Elaboration of quinquepyridine 27 to the pyridinium salt 30 bearing a protected enal allowed for the synthesis of 2 by a one-pot deprotection/Kroehnke reaction in nine steps from 4,4′-bipyridine. Use of the Kroehnke pyridine synthesis has been applied to prepare sexipyridine dibromide 19, but attempts to induce a macrocyclization via metal-mediated (Pd/Ni/Cu) aryl-aryl coupling procedures proved unsuccessful. Acetylene-bridged sexipyridines 3a and 3b incorporating 2,2′-bipyridine units proved to be inaccessible via sp-sp2 or sp-sp coupling protocols.
