18921-68-1 Usage
Description
Deaza-Aminopterin is a synthetic derivative of the drug aminopterin, characterized by its ability to inhibit the enzyme dihydrofolate reductase. This enzyme plays a crucial role in the synthesis of nucleic acids, such as DNA and RNA, making it a significant target for cancer chemotherapy. Deaza-Aminopterin functions by obstructing the synthesis of these nucleic acids, which in turn disrupts the growth and proliferation of cancer cells.
Uses
Used in Cancer Chemotherapy:
Deaza-Aminopterin is utilized as a chemotherapy agent for its potential to treat various types of cancer. It has demonstrated promising results in preclinical studies, particularly for conditions such as acute lymphoblastic leukemia, non-Hodgkin's lymphoma, and solid tumors. Deaza-Aminopterin's mechanism of action involves blocking the synthesis of nucleic acids, which is essential for cancer cell growth and proliferation.
Check Digit Verification of cas no
The CAS Registry Mumber 18921-68-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,9,2 and 1 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 18921-68:
(7*1)+(6*8)+(5*9)+(4*2)+(3*1)+(2*6)+(1*8)=131
131 % 10 = 1
So 18921-68-1 is a valid CAS Registry Number.
InChI:InChI=1/C21H22N6O5/c22-18-14-9-11(1-6-15(14)26-21(23)27-18)10-24-13-4-2-12(3-5-13)19(30)25-16(20(31)32)7-8-17(28)29/h1-6,9,16,24H,7-8,10H2,(H,25,30)(H,28,29)(H,31,32)(H4,22,23,26,27)
18921-68-1Relevant articles and documents
Chemistry and Antitumor Evaluation of Selected Classical 2,4-Diaminoquinazoline Analogues of Folic Acid
Hynes, J.B.,Harmon, S.J.,Floyd, G.G.,Farrington, M.,Hart, L.D.,et al.
, p. 209 - 215 (2007/10/02)
A series of six 2,4-diaminoquinazoline analogues of folic acid which bear close structural resemblance to methotrexate, 1a, were synthesized by unequivocal routes.Three of these have not been described previously, while complete structural characterizatio
