189245-00-9Relevant articles and documents
Efficient synthesis of (S)-(-)- and (R)-(+)-enantiomers of 15-deoxyspergualin (15-DSG)
Wang, Xuebao,Thottathil, John
, p. 3665 - 3669 (2000)
An efficient synthesis of the (S)-(-)- and (R)-(+)-enantiomers of 15-deoxyspergualin (15-DSG) is reported. The synthesis involves preparative HPLC separation and subsequent hydrogenolysis of two diastereoisomers 10a and 10b of fully protected 15-DSG penultimates. Alternatively, diastereomerically pure amide 10b (97% de) was also prepared from acid 8b (97% de), which was obtained via crystallization of a 1:1 diastereomeric mixture of 8a and 8b. Copyright (C) 2000 Elsevier Science Ltd.