189256-22-2

Basic information

• Product Name: Adenosine, N-benzoyl-2'-O-(tetrahydro-2H-pyran-2-yl)-, 5'-[2-[[(1,4-dioxopentyl)oxy]methyl]benzoate]
• CAS NO: 189256-22-2
• Molecular Formula: C35H37N5O10
• Molecular Weight: 687.706
• Mol File: 189256-22-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Adenosine, N-benzoyl-2'-O-(tetrahydro-2H-pyran-2-yl)-, 5'-[2-[[(1,4-dioxopentyl)oxy]methyl]benzoate](CAS DataBase Reference)
• NIST Chemistry Reference: Adenosine, N-benzoyl-2'-O-(tetrahydro-2H-pyran-2-yl)-, 5'-[2-[[(1,4-dioxopentyl)oxy]methyl]benzoate](189256-22-2)
• EPA Substance Registry System: Adenosine, N-benzoyl-2'-O-(tetrahydro-2H-pyran-2-yl)-, 5'-[2-[[(1,4-dioxopentyl)oxy]methyl]benzoate](189256-22-2)

Safety Data

• Hazardous Substances Data: 189256-22-2(Hazardous Substances Data)

Upstream product

• 612-20-4 2-(hydroxymethyl)benzoic acid 
• 87-41-2 2-benzofuran-1(3H)-one 
• 31505-87-0 6-N-benzoyl-2'-O-(tetrahyropyran-2-yl)adenosine 
• 189256-18-6 2-(4-Oxo-pentanoyloxymethyl)-benzoic acid 

Downstream Products

• 189256-30-2 2-(4-Oxo-pentanoyloxymethyl)-benzoic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-3-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester 

Relevant articles and documents

Oligonucleotide synthesis by the use of a 2-(levulinyloxymethyl)-5-nitrobenzoyl group as the novel base-labile protecting group for the 5'-hydroxyl groups of ribonucleoside and 2'-deoxyribonucleoside 3'-phosphoramidites

A novel 2-(levulinyloxymethyl)-5-nitrobenzoyl (LMNBz) protecting group for the 5' position of nucleoside 3'-phosphoramidites was successfully applied to the solid-phase synthesis of both an oligodeoxyribonucleotide (TpTpT and TpTpTpT) and an octaribonucleotide in combination with a 2'-O-Thp protecting group (UpCpApGpUpUpGpG). The LMNBz group was simply unmasked due to its base-labile property by a two-step procedure, i.e., treatments with 0.5 M hydrazine hydrate in 1:4 acetic acid - pyridine, and then with 0.5 M imidazole in acetonitrile.