189323-03-3Relevant articles and documents
Piperidine carboxylic acid derivatives as sialyl Lewis X mimetics
Toepfer, Alexander,Kretzschmar, Gerhard
, p. 1311 - 1316 (1997)
Four piperidine carboxylic acid derivatives designed as mimetics of the sialyl Lewis X determinant were synthesized. Their inhibitory potency for selectin mediated cell adhesion was evaluated in cell culture assays, in vivo and in a reperfusion model. Compound 7 showed strong inhibition of leukocyte adhesion in rats and a powerful decrease of the incidence of arrhythmias in a reperfusion model in isolated rabbit hearts.