18938-22-2Relevant articles and documents
Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors
Byrd, Katherine M.,Subramanian, Chitra,Sanchez, Jacqueline,Motiwala, Hashim F.,Liu, Weiya,Cohen, Mark S.,Holzbeierlein, Jeffrey,Blagg, Brian S. J.
, p. 6921 - 6931 (2016)
Development of heat shock protein 90 (Hsp90) C-terminal inhibitors has emerged as an exciting strategy for the treatment of cancer. Previous efforts have focused on modifications to the natural products novobiocin and coumermycin. Moreover, variations in both the sugar and amide moieties have been extensively studied, whereas replacements for the coumarin core have received less attention. Herein, 24 cores were synthesized with varying distances and angles between the sugar and amide moieties. Compounds that exhibited good anti-proliferative activity against multiple cancer cell lines and Hsp90 inhibitory activity, were those that placed the sugar and amide moieties between 7.7 and 12.1 ? apart along with angles of 180°.
SUBSTITUTED UREA DERIVATIVES AND PHARMACEUTICAL USES THEREOF
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Paragraph 00389, (2016/02/10)
Provided herein are novel substituted urea derivatives, and pharmaceutical compositions thereof. Also provided herein are uses of the compounds or pharmaceutical compositions thereof for preventing, managing, treating or lessening a proliferative disease, andmodulating the activity of protein kinase.
Photochromic oxazines with extended conjugation
Petersen, Michael Axman,Deniz, Erhan,Nielsen, Mogens Brondsted,Sortino, Salvatore,Raymo, Francisco M.
supporting information; experimental part, p. 4333 - 4339 (2011/02/24)
We synthesized four compounds with indole and benzooxazine fragments fused in their molecular skeleton and differing in the substituent in the para position, relative to the oxygen atom, of their phenoxy chromophore. This particular substituent extends th
