1895-97-2

Basic information

• Product Name: α-Methylcinnamic acid
• Synonyms: (E)-2-Methyl-3-phenylpropenoic acid;(E)-3-Phenylmethacrylic acid;(E)-α-Benzylidenepropionic acid;trans-α-Methylcinnamic acid;α-Methyl-trans-cinnamic acid
• CAS NO: 1895-97-2
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.1852
• Mol File: 1895-97-2.mol
• Article Data: 50

Chemical Properties

• Melting Point: 80 °C
• Boiling Point: 248.88°C (rough estimate)
• Appearance: /
• Density: 1.0613 (rough estimate)
• Refractive Index: 1.5120 (estimate)
• Solubility: soluble in Methanol
• Water Solubility: 3.5g/L(25 oC)
• CAS DataBase Reference: α-Methylcinnamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: α-Methylcinnamic acid(1895-97-2)
• EPA Substance Registry System: α-Methylcinnamic acid(1895-97-2)

Safety Data

• Hazardous Substances Data: 1895-97-2(Hazardous Substances Data)

Usage

General Description

α-Methylcinnamic acid, also known as 2-Methyl-3-phenyl-2-propenoic acid, is a synthetic, crystalline chemical compound that belongs to the class of cinnamic acids. It is derived from cinnamic acid and has a molecular formula of C10H10O2. α-Methylcinnamic acid is commonly used as a flavor and fragrance enhancer in various products such as cosmetics, soaps, and perfumes. It is also used in the pharmaceutical industry as an intermediate for the synthesis of active pharmaceutical ingredients. Furthermore, α-Methylcinnamic acid has been studied for its potential antioxidant and anti-inflammatory properties, making it a subject of interest in the field of medicinal chemistry.

Upstream product

• 42968-14-9 (E)-3-methyl-4-phenyl-3-buten-2-one 
• 24744-96-5 ethyl 3-hydroxy-2-methyl-3-phenylpropionate 
• 554-12-1 propanoic acid methyl ester 
• 100-52-7 benzaldehyde 
• 516-05-2 methyl-propanedioic acid 
• 71660-00-9 propionic acid pin-2-en-10-yl ester 
• 123-62-6 propionic acid anhydride 
• 673-32-5 1-Phenylprop-1-yne 
• 124-38-9 carbon dioxide 
• 22946-43-6 (E)-methyl-2-methyl-3-phenylacrylate 
• 39934-05-9 endo-1,5-dimethyl-2,3,4,6,7-pentaphenyltricyclo<3.2.1.0^2,4>-6-octen-8-one 
• 598-72-1 2-Bromopropionic acid 
• 79140-73-1 (E)-2-Methyl-3-phenyl-1-trimethylsilanyl-propenone 
• 93440-91-6 (3E)-3-Methyl-2-oxo-4-phenyl-3-butensaeure (Kaliumsalz) 

Downstream Products

• 15250-29-0 (Z)-2-methyl-3-phenylprop-2-enoic acid 
• 1009-67-2 2-methyl-3-phenylpropanoic acid 
• 66482-10-8 (2RS:3SR)-2,3-dibromo-2-methyl-3-phenyl-propionic acid 
• 107619-42-1 (+/-)-1-methyl-6t-phenyl-cyclohex-3-ene-r-carboxylic acid 
• 1504-55-8 (E)-3-phenyl-2-methyl-2-propenol 
• 7042-33-3 ethyl (E)-2-methyl-3-phenyl-2-propenoate 
• 92593-15-2 selenophenyl α-methylcinnamate 
• 25547-51-7 trans-2-methyl-3-phenyloxiranecarboxylic acid 
• 70841-95-1 2-methyl-3-phenylpropanoic acid-α,β-d₂ 
• 71001-35-9 (2-bromoprop-1-en-1-yl)benzene 
• 35086-87-4 (E)-2-methyl-3-phenylacryloyl chloride 
• 33066-18-1 (E)-α-Methylzimtsaeureazid 
• 14367-67-0 2-methyl-3-phenylpropionic acid 
• 1009-67-2 2-methyl-3-phenylpropionic acid 

Relevant articles and documents

Method for synthesizing alkyl olefin through coupling of double-bond carbon-hydrogen bond and saturated carbon-hydrogen bond

The invention discloses a method for synthesizing alkyl olefin through coupling of a double-bond carbon-hydrogen bond and a saturated carbon-hydrogen bond. According to to the method, one-pot reactionis implemented on olefin and sulfoxide in the presence of ferric salt and hydrogen peroxide to generate alkyl olefin; in the method, sulfoxide is simultaneously used as a hydrocarbylation reagent anda solvent of olefin, and a reaction product is alkyl olefin from sulfoxide alkyl coupled with olefin carbon atoms, so that an olefin carbon chain is increased; the reaction conditions are mild, the selectivity is good, the yield is high, and industrial production is facilitated.

The synergistic copper/ppm Pd-catalyzed hydrocarboxylation of alkynes with formic acid as a CO surrogate as well as a hydrogen source: An alternative indirect utilization of CO2

An unprecedented strategy has been developed involving the earth-abundant Cu-catalyzed hydrocarboxylation of alkynes with HCOOH to (E)-acrylic derivatives with high regio- and stereoselectivity via synergistic effects with ppm levels of a Pd catalyst. Both symmetrical and unsymmetrical alkynes bearing various functional groups were successfully hydrocarboxylated with HCOOH, and the modification of a pharmaceutical molecule exemplified the practicability of this process. This protocol employs HCOOH as both a CO surrogate and hydrogen donor with 100% atom economy and it can be viewed as an alternative approach for indirect CO2 utilization. Mechanistic investigations indicate a Cu/ppm Pd cooperative catalysis mechanism via alkenylcopper species as potential intermediates formed from Cu-hydride active catalytic species with HCOOH as a hydrogen source. This bimetallic system involving inexpensive Cu and trace Pd provides a reliable and efficient hydrocarboxylation method to access industrially useful acrylic derivatives with HCOOH as a hydrogen source, and it provides novel clues for optimizing other Cu-H-related co-catalytic systems.

Method for preparing alpha, beta-unsaturated carboxylic acid compound

The invention discloses a method for preparing an alpha, beta-unsaturated carboxylic acid compound, which comprises the following steps: 1) in an atmosphere containing carbon dioxide, heating and reacting a mixture containing hydrosilane and a copper catalyst to obtain a system I; and 2) adding a raw material containing alkyne and a nickel catalyst into the system I in the step 1), and heating to react. The method has the advantages of simple, easily available, cheap and stable raw materials, common, easily available and stable catalyst, mild reaction conditions, simple post-treatment, high yield and the like.