1895006-01-5 Usage
Description
Dimesityl(trifluoromethyl)sulfonium trifluoromethanesulfonate, also known as the Mes-Umemoto reagent, is a chemical compound that serves as an effective reagent for the trifluoromethylation of alkyl halides and aryl halides. It is characterized by its ability to yield alkyl-CF3 and aryl-CF3 products in high yields, showcasing a wide substrate scope and good functional group tolerance.
Uses
Used in Pharmaceutical Industry:
Dimesityl(trifluoromethyl)sulfonium trifluoromethanesulfonate is used as a reagent for the trifluoromethylation of alkyl halides and aryl halides for the synthesis of various pharmaceutical compounds. The application reason is its ability to provide high yields of alkyl-CF3 and aryl-CF3 products with a wide substrate scope and good functional group tolerance.
Used in Chemical Research:
Dimesityl(trifluoromethyl)sulfonium trifluoromethanesulfonate is used as a reagent in the field of chemical research for the trifluoromethylation of various substrates. The application reason is its effectiveness in yielding high yields of the desired products, even with a variety of 5-membered and 6-membered heteroaryl halides, under mild conditions.
Used in Conjunction with Supersilanol and Ir Photocatalyst:
Dimesityl(trifluoromethyl)sulfonium trifluoromethanesulfonate is used in combination with supersilanol (902489) and Ir photocatalyst (902217 or 902225) for enhanced trifluoromethylation reactions. The application reason is to improve the efficiency and selectivity of the trifluoromethylation process under a dual catalytic copper/photoredox manifold.
Check Digit Verification of cas no
The CAS Registry Mumber 1895006-01-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,9,5,0,0 and 6 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1895006-01:
(9*1)+(8*8)+(7*9)+(6*5)+(5*0)+(4*0)+(3*6)+(2*0)+(1*1)=185
185 % 10 = 5
So 1895006-01-5 is a valid CAS Registry Number.
1895006-01-5Relevant articles and documents
Palladium-Catalyzed Arylation of Arylboronic Acids with Yagupolskii-Umemoto Reagents
Wang, Shi-Meng,Wang, Xiao-Yan,Qin, Hua-Li,Zhang, Cheng-Pan
, p. 6542 - 6546 (2016)
A Pd-catalyzed Suzuki cross-coupling of arylboronic acids with Yagupolskii-Umemoto reagents was explored. In contrary to trifluoromethylations, the Pd-catalyzed reaction of R-B(OH)2 and [Ar2SCF3]+[OTf]- provided the arylation products (R-Ar) in good to high yields. The reaction confirms that the S-Ar bonds of [Ar2SCF3]+[OTf]- can be readily cleaved in the presence of Pd complexes. The relatively electron-poor aryl groups of asymmetric [Ar1Ar2SCF3]+[OTf]- salts are more favorably transferred compared to the electron-rich ones. This reaction represents the first report of utilization of [Ar2SCF3]+[OTf]- as arylation reagents in organic synthesis.
