189580-34-5Relevant articles and documents
Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes
Poreba, Marcin,Solberg, Rigmor,Rut, Wioletta,Lunde, Ngoc Nguyen,Kasperkiewicz, Paulina,Snipas, Scott J.,Mihelic, Marko,Turk, Dusan,Turk, Boris,Salvesen, Guy S.,Drag, Marcin
, p. 1023 - 1034 (2016)
Legumain (AEP) is a lysosomal cysteine protease that was first characterized in leguminous seeds and later discovered in higher eukaryotes. AEP upregulation is linked to a number of diseases including inflammation, arteriosclerosis, and tumorigenesis. Thu
CuI-promoted one-pot synthesis of N-boc protected β-ketotriazole amino acids: Application in the synthesis of new class of dipeptidomimetics
Vishwanathaa,Narendra,Sureshbabu, Vommina V.
experimental part, p. 308 - 314 (2012/07/17)
One-pot click chemistry of Nα-Boc-bromomethylketones, NaN3 and propiolic acid affords N-Boc protected 1,4- disubstituted 1,2,3-β-ketotriazole acids in good to excellent yield. The use of CuI as catalyst and DMSO as solvent leads the click react