18960-19-5

Basic information

• Product Name: 1,4-dioxopyrazinamide
• Synonyms: 1,4-dioxopyrazinamide
• CAS NO: 18960-19-5
• Molecular Weight: 155.113
• Mol File: 18960-19-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,4-dioxopyrazinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-dioxopyrazinamide(18960-19-5)
• EPA Substance Registry System: 1,4-dioxopyrazinamide(18960-19-5)

Safety Data

• Hazardous Substances Data: 18960-19-5(Hazardous Substances Data)

Upstream product

• 98-96-4 pyrazinamide 

Downstream Products

• 356783-31-8 6-fluoro-3-hydroxypyrazine-2-carbonitrile 
• 356783-16-9 3,6-dichloropyrazine-2-carbonitrile 
• 259793-96-9 favipiravir 
• 356783-29-4 3,6-difluoropyrazine-2-carboxamide 
• 356783-28-3 3,6-difluoropyrazine-2-carbonitrile 

Relevant articles and documents

Synthesis, antimycobacterial and antifungal evaluation of 3-arylaminopyrazine-2,5-dicarbonitriles

This paper describes preparation and biological evaluation of pyrazinamide analogues. Pyrazinamide with its simple structure gives a good opportunity for further modification regarding an increase of its antimycobacterial activity. We prepared a series of compounds derived from pyrazine-2,5-dicarbonitrile with arylamino substitution in position 3. All compounds were assayed in vitro against major Mycobacterium and various Fungi species. The best activity was found in 3-{[3-(trifluoromethyl)phenyl]amino}pyrazine-2,5-dicarbonitrile 11 with the value of 6.25 μmol-1 against M. tuberculosis H37Rv and moderate activity against minor Mycobacterium pathogens.