189625-51-2Relevant articles and documents
Method for preparing long aliphatic chain diacid derivative and application of long aliphatic chain diacid derivative
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, (2021/07/01)
The invention provides a method for preparing a long aliphatic chain diacid derivative. The method comprises the following steps of: (1) carrying out a cyclization reaction on long aliphatic chain diacid, the long aliphatic chain diacid having a structure as shown in a formula (A); (2) reacting the long aliphatic chain diacid cyclization product with benzyl alcohol to obtain long aliphatic chain diacid monobenzyl ester; (3) carrying out an esterification reaction on the long aliphatic chain diacid monobenzyl ester and N-hydroxysuccinimide so as to obtain long aliphatic chain diacid succinimide benzyl ester; (4) carrying out a nucleophilic addition amidation reaction on the long aliphatic chain diacid succinimide benzyl ester and a compound as shown in a formula (B) to obtain a compound as shown in a formula (C); (5) carrying out an esterification reaction on the compound as shown in the formula (C) and N-hydroxysuccinimide again so as to obtain a compound as shown in a formula (D); and (6) carrying out a debenzylation reaction on the compound shown in the formula (D) so as to obtain a compound shown in a formula (E).
Method for preparing alkyl diacid monobenzyl ester
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Paragraph 0031-0032, (2019/12/25)
The invention relates to a method for preparing an alkyl diacid monobenzyl ester, and belongs to the technical field of chemical engineering. According to the method provided by the invention, an alkyl diacid is used as a raw material and is subjected to esterification reaction with benzyl bromide or benzyl chloride in a mixed system of an organic solvent and water under the action of an alkali toobtain the alkyl diacid monobenzyl ester. The method is good in selectivity, convenient to operate, high in yield, low in cost and beneficial to implementation.
