189684-53-5

Basic information

• Product Name: AC-VDVAD-PNA
• Synonyms: CASPASE 2 SUBSTRATE, CHROMOGENIC;CASPASE-2 SUBSTRATE IV;CASPASE-2 SUBSTRATE IV, COLORIMETRIC;CASPASE 2 (ICH-1) SUBSTRATE 1, CHROMOGENIC;AC-VAL-ASP-GLN-GLN-ASP-PARANITROANILIDE;AC-VAL-ASP-GLN-GLN-ASP-PNA;AC-VAL-ASP-VAL-ALA-ASP-PARANITROANILIDE;AC-VAL-ASP-VAL-ALA-ASP-PNA
• CAS NO: 189684-53-5
• Molecular Formula: C29H41N7O12
• Molecular Weight: 679.68
• Product Categories: peptide;Caspase/Related Products;Pepetides
• Mol File: 189684-53-5.mol
• Article Data: 0

Chemical Properties

• Appearance: /powder
• Storage Temp.: −20°C
• Solubility: DMSO: 2 mM
• CAS DataBase Reference: AC-VDVAD-PNA(CAS DataBase Reference)
• NIST Chemistry Reference: AC-VDVAD-PNA(189684-53-5)
• EPA Substance Registry System: AC-VDVAD-PNA(189684-53-5)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 189684-53-5(Hazardous Substances Data)

Usage

Description

AC-VDVAD-PNA, also known as Acetyl-Asp-Val-Ala-Asp-Ala-Asn-4-nitroanilide, is a synthetic peptide substrate that serves as a specific and sensitive chromogenic substrate for the detection and measurement of caspase-2 activity. It is designed to mimic the natural substrate sequence of caspase-2, allowing for the accurate assessment of enzyme activity in various experimental settings.

Uses

Used in Research Applications:
AC-VDVAD-PNA is used as a research tool for the study of caspase-2 activity, particularly in the context of apoptosis and cell death mechanisms. It provides a convenient and reliable method for monitoring caspase-2 activity in vitro, enabling researchers to investigate the role of this enzyme in various biological processes and disease states.
Used in Drug Discovery and Development:
AC-VDVAD-PNA is employed as a screening tool in drug discovery and development, particularly for the identification and optimization of caspase-2 inhibitors or activators. By monitoring the effects of potential drug candidates on caspase-2 activity using this substrate, researchers can evaluate the efficacy and selectivity of these compounds in modulating caspase-2 function.
Used in Diagnostic Applications:
AC-VDVAD-PNA can be utilized in diagnostic assays to detect and quantify caspase-2 activity in clinical samples, such as blood or tissue extracts. This can aid in the diagnosis and monitoring of diseases associated with abnormal caspase-2 activity, as well as in the assessment of treatment efficacy for such conditions.
Used in Educational Applications:
AC-VDVAD-PNA serves as an educational tool for teaching students about the role of caspase-2 in apoptosis and cell death, as well as the principles of enzyme kinetics and substrate specificity. By using this substrate in laboratory exercises and demonstrations, educators can help students gain a deeper understanding of these important biological concepts.