189937-46-0 Usage
Description
FMOC-D-3,3-DIPHENYLALANINE, also known as Fmoc-d-3,3-diphenylalanine, is an amino acid building block derived from the naturally occurring amino acid phenylalanine. It is characterized by its D-configuration and the presence of two phenyl groups at the 3,3-position. FMOC-D-3,3-DIPHENYLALANINE is a white powder and is widely used in the synthesis of peptides due to its unique structural properties.
Uses
Used in Pharmaceutical Industry:
FMOC-D-3,3-DIPHENYLALANINE is used as a building block for peptide synthesis for the development of new pharmaceuticals. Its unique structure allows for the creation of novel peptide-based drugs with potential applications in various therapeutic areas.
Used in Research and Development:
FMOC-D-3,3-DIPHENYLALANINE is used as a research tool for studying the properties and functions of peptides containing this specific amino acid. It can be employed in the design and synthesis of bioactive peptides for understanding their interactions with biological targets and potential therapeutic effects.
Used in Peptide Drug Market:
FMOC-D-3,3-DIPHENYLALANINE is used as a key component in the fast and reliable synthesis of peptides, which is of great importance in the growing peptide drug market. Its incorporation into peptide sequences can lead to the development of innovative and effective peptide-based therapeutics.
Check Digit Verification of cas no
The CAS Registry Mumber 189937-46-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,9,3 and 7 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 189937-46:
(8*1)+(7*8)+(6*9)+(5*9)+(4*3)+(3*7)+(2*4)+(1*6)=210
210 % 10 = 0
So 189937-46-0 is a valid CAS Registry Number.
InChI:InChI=1/C30H25NO4/c32-29(33)28(27(20-11-3-1-4-12-20)21-13-5-2-6-14-21)31-30(34)35-19-26-24-17-9-7-15-22(24)23-16-8-10-18-25(23)26/h1-18,26-28H,19H2,(H,31,34)(H,32,33)/t28-/m1/s1
189937-46-0Relevant articles and documents
The effects of conformational constraints and steric bulk in the amino acid moiety of philanthotoxins on AMPAR antagonism
J?rgensen, Malene R.,Olsen, Christian A.,Mellor, Ian R.,Usherwood, Peter N. R.,Witt, Matthias,Franzyk, Henrik,Jaroszewski, Jerzy W.
, p. 56 - 70 (2007/10/03)
Philanthotoxin-343 (PhTX-343), a synthetic analogue of wasp toxin PhTX-433, is a noncompetitive antagonist at ionotropic receptors (e.g., AChR or iGluR). To determine possible effects of variations of the amino acid side chain, a library consisting of seventeen PhTX-343 analogues was prepared. Thus, tyrosine was replaced by either apolar, conformationally constrained, or bulky amino acids, whereas the acyl unit and the polyamine moiety were kept unchanged. Analogues with tertiary amide groups were prepared for the first time. Pentafluorophenyl esters were employed for amide bond formation, establishing general protocols for philanthotoxin solution- and solid-phase synthesis (39-90% and 42-54% overall yields, respectively). The analogues were tested for their ability to antagonize kainate-induced currents of 2-amino-3-(3-hydroxy-5-methyl- 4-isoxazoyl)propanoic acid receptors (AMPAR) expressed in Xenopus oocytes from rat brain mRNA. This showed that steric bulk in the amino acid moiety is well tolerated and suggests that binding to AMPAR does not involve the α-NHCO group as a donor in hydrogen bonding.
