189954-65-2 Usage
Description
3-(5-Bromopyridin-2-yloxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2(5H)-one is a complex organic compound characterized by its unique molecular structure. It is a part of the Aryl Halide Chemistry Informer Library, which is a collection of drug-like molecules used for the development and analysis of new chemical reactions and methodologies in the field of pharmaceutical chemistry.
Uses
Used in Pharmaceutical Chemistry Research:
3-(5-Bromopyridin-2-yloxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2(5H)-one is used as an Informer compound in the Aryl Halide Chemistry Informer Library for [application type] method development and analysis in pharmaceutical chemistry. It serves as a representative molecule to compare and analyze the successes and shortcomings of new reactions among different methods and research teams, ultimately aiding in the development of more efficient and effective chemical synthesis processes.
Used in Drug Synthesis and Optimization:
In the field of drug synthesis, 3-(5-Bromopyridin-2-yloxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2(5H)-one is used as a key intermediate or building block for the creation of novel drug candidates. Its unique structure allows for further functionalization and modification, making it a valuable asset in the design and optimization of new pharmaceutical compounds with improved performance and utility.
Used in Academic and Industrial Research:
3-(5-Bromopyridin-2-yloxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2(5H)-one is also utilized in academic and industrial research settings as a test molecule for evaluating the performance of new synthetic methods, catalysts, and reaction conditions. Its inclusion in the Informer Library enables researchers to benchmark their findings against a standardized set of compounds, facilitating collaboration and knowledge sharing across the scientific community.
Check Digit Verification of cas no
The CAS Registry Mumber 189954-65-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,9,5 and 4 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 189954-65:
(8*1)+(7*8)+(6*9)+(5*9)+(4*5)+(3*4)+(2*6)+(1*5)=212
212 % 10 = 2
So 189954-65-2 is a valid CAS Registry Number.
189954-65-2Relevant articles and documents
Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors
Lau, Cheuk K.,Brideau, Christine,Chan, Chi Chung,Charleson, Stella,Cromlish, Wanda A.,Ethier, Diane,Yves Gauthier, Jacques,Gordon, Robert,Guay, Jocelyne,Kargman, Stacia,Li, Chun-Sing,Prasit, Petpiboon,Riendeau, Denis,Therien, Michel,Visco, Denise M.,Xu, Lijing
, p. 3187 - 3192 (2007/10/03)
A series of 3-heteroaryloxy-4-phenyl-2-(5H)-furanones were prepared and evaluated for their potency and selectivity as COX-2 inhibitors. This led to the identification of L-778,736 as a potent, orally active and selective inhibitor of the COX-2 enzyme.
