19006-81-6

Basic information

• Product Name: 2-HYDROXY-4-PHENYLPYRIDINE
• Synonyms: 2-HYDROXY-4-PHENYLPYRIDINE;4-PHENYL-2-PYRIDINONE;4-Phenyl-2(1H)-pyridinone;4-Phenylpyridine-2(1H)-one;4-Phenylpyridin-2-ol;4-Phenyl-1H-pyridin-2-one;4-Phenyl-2(1H)-pyridone;4-Phenyl-2-pyridone
• CAS NO: 19006-81-6
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.2
• Mol File: 19006-81-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 229-231℃
• Boiling Point: 395℃
• Flash Point: 233℃
• Appearance: /
• Density: 1.158
• Vapor Pressure: 1.94E-06mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11?+-.0.10(Predicted)
• CAS DataBase Reference: 2-HYDROXY-4-PHENYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-4-PHENYLPYRIDINE(19006-81-6)
• EPA Substance Registry System: 2-HYDROXY-4-PHENYLPYRIDINE(19006-81-6)

Safety Data

• Hazardous Substances Data: 19006-81-6(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-4-phenylpyridine is a chemical compound with the molecular formula C11H9NO. It is a derivative of pyridine and bears a hydroxy group and a phenyl group on the 2 and 4 positions of the pyridine ring, respectively. 2-HYDROXY-4-PHENYLPYRIDINE has the potential to be used in various applications such as in pharmaceuticals, agrochemicals, and material science due to its unique structure and properties. It may also have potential biological activities and can be used as a building block in organic synthesis. However, further research and testing are needed to fully understand and utilize its potential uses.

InChI:InChI=1/C11H9NO/c13-11-8-10(6-7-12-11)9-4-2-1-3-5-9/h1-8H,(H,12,13)

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 41220-29-5 N-carbamoylmethylpyridinium chloride 
• 392658-01-4 2-benzyloxy-6-chloro-4-phenyl-pyridine 
• 40673-25-4 4-chloro-2-hydroxypyridine 
• 143-66-8 sodium tetraphenyl borate 
• 2587-02-2 2,6-dichloro-[4]pyridylamine 
• 98027-84-0 2,6-dichloro-4-iodopyridine 
• 25297-51-2 2,6-dichloro-4-phenylpyridine 
• 98-80-6 phenylboronic acid 
• 1131-61-9 4-Phenylpyridine 1-oxide 
• 109-89-7 diethylamine 
• 107-91-5 cyanoacetic acid amide 
• 104-55-2 3-phenyl-propenal 

Downstream Products

• 1105690-62-7 ethyl 4-methyl-2-(2-oxo-4-phenylpyridin-1(2H)-yl)thiazole-5-carboxylate 
• 1312478-87-7 ethyl 2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanoate 
• 1312479-41-6 ethyl 2-ethyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanoate 
• 1358778-32-1 ethyl (2R)-2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanoate 
• 127956-40-5 1-<2-cyano-1-(4-chlorophenyl)-ethenyl>4-phenyl-2(1H)-pyridinone 
• 127956-37-0 1-<2-cyano-1-(4-methoxyphenyl)-ethenyl>4-phenyl-2(1H)-pyridinone 
• 53698-46-7 2-methoxy-4-phenyl-pyridine 
• 67970-80-3 1-methyl-4-phenyl-2(1H)-pyridone 
• 37520-85-7 (1R,8R)-9-Methyl-11-phenyl-9-aza-tricyclo[6.2.2.0^2,7]dodeca-2⁽⁷⁾,3,5,11-tetraen-10-one 
• 1202927-35-2 N-benzyl-2-(2-oxo-4-phenylpyridn-1(2H)-yl)isonicotinamide 
• 1370698-60-4 C₂₆H₂₂F₂N₄O 
• 1042036-55-4 1-benzyl-4-phenyl-1H-pyridin-2-one 

Relevant articles and documents

Magnesiate-Utilized/Benzyne-Mediated Approach to Indenopyridones from 2-Pyridones: An Attempt to Synthesize the Indenopyridine Core of Haouamine

An efficient, short-staged synthesis of cis-fused indeno[2,1-b]- and indeno[1,2-c]pyridin-2-ones, starting from 2-pyridones, using magnesiates of type R3MgLi as nucleophilic and deprotonation agents, mediated by benzyne generated in situ, under optimized conditions, is described. Following the developed protocol, rare C4a-arylsubstituted indeno[2,1-b]pyridones, resembling the core of haouamine, were obtained. The protocol offering the one-pot synthesis directly from 2-pyridone is also described.

ORGANIC COMPOUNDS

The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.

8-AZABICYCLO[3.2.1]OCTANE DERIVATIVES USEFUL AS MONOAMINE REUPTAKE INHIBITORS

The present invention relates to a 8-azabicyclo[3.2.1]octane derivative of Formula I, wherein R1 is H or C1-5alkyl; Y is O, S or O(CH2)m; m is 1 or 2; n is 0 or 1; Ar1 is phenylene or pyridylene, said phenylene and pyridylene being 1,3-linked with respect to O and when n is 1 with Y and when n is 0 with Ar2, said phenylene or pyridylene being optionally substituted with one or two substituents independently selected from halogen, C1-5alkyl, C1-5alkoxy, C3-6cycloalkyl, C2-5alkenyl, C2-5alkynyl, phenyl, CN and hydroxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein the oxygen of said hydroxy is optionally bonded to Ar2 to form a 5-membered ring; Ar2 is phenyl or a 5-6 membered heteroaryl, said phenyl or 5-6 membered heteroaryl being optionally substituted with one to three substituents independently selected from halogen, C1-5alkyl, C1-5alkoxy, CN, CONR2R3, CO2R4, NHCOR5 and hydroxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein the oxygen of said hydroxy is optionally bonded to Ar1 to form a 5-membered ring; R2-R4 are independently H or C1-5alkyl and R5 is C1-5alkyl, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising a 8- azabicyclo[3.2.1]octane derivative according to the present invention in admixture with one or more pharmaceutically acceptable auxiliaries and to the use of a 8- azabicyclo[3.2.1]octane derivative according to the present invention in therapy.