190071-25-1

Basic information

• Product Name: 1H-Indole-5-carboxylic acid, 2-phenyl-, methyl ester
• CAS NO: 190071-25-1
• Molecular Formula: C16H13NO2
• Molecular Weight: 251.285
• Mol File: 190071-25-1.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 1H-Indole-5-carboxylic acid, 2-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-5-carboxylic acid, 2-phenyl-, methyl ester(190071-25-1)
• EPA Substance Registry System: 1H-Indole-5-carboxylic acid, 2-phenyl-, methyl ester(190071-25-1)

Safety Data

• Hazardous Substances Data: 190071-25-1(Hazardous Substances Data)

Usage

General Description

1H-Indole-5-carboxylic acid, 2-phenyl-, methyl ester is a chemical compound with the molecular formula C18H15NO2. It is commonly referred to as 2-phenylindole-5-carboxylic acid methyl ester. 1H-Indole-5-carboxylic acid, 2-phenyl-, methyl ester is a derivative of indole, which is a bicyclic heterocyclic organic compound. It is often used in organic synthesis and pharmaceutical research due to its potential biological and pharmacological properties. 1H-Indole-5-carboxylic acid, 2-phenyl-, methyl ester is known to exhibit anti-inflammatory and analgesic activities, and it also has potential anticancer properties. Additionally, it has been studied for its potential use in the treatment of neurodegenerative diseases and as a building block in the synthesis of various pharmaceutical compounds.

Upstream product

• 884302-70-9 3-bromo-4-(2,2,2-trifluoro-acetylamino)-benzoic acid methyl ester 
• 536-74-3 phenylacetylene 
• 848485-43-8 methyl 3-iodo-4-(2,2,2-trifluoroacetamido)benzoate 
• 1011-65-0 5-methoxycarbonylindole 
• 613-94-5 benzoic acid hydrazide 
• 98-09-9 benzenesulfonyl chloride 
• 100-42-5 styrene 
• 19718-49-1 4-amino-3-iodobenzoic acid methyl ester 
• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 
• 886853-77-6 4-amino-3-(2,2-dibromo-vinyl)-benzoic acid methyl ester 
• 150-13-0 4-amino-benzoic acid 
• 190071-24-0 4-acetylamino-3-iodo-benzoic acid 
• 109434-07-3 2-(2-nitro-5-carbomethoxyphenyl)-1-phenylethanol 

Downstream Products

• 1059628-79-3 (2-phenyl-1H-indol-5-yl)-methanol 
• 110073-82-0 2-phenyl-1H-indole-5-carboxylic acid 
• 1154061-04-7 methyl 1-(2-methoxyethyl)-2-phenyl-1H-indole-5-carboxylate 

Relevant articles and documents

Characterization of heterogeneous aryl-Pd(ii)-oxo clusters as active species for C-H arylation

C-H arylation with heterogeneous palladium was investigated. The surface oxidation of Pd nanoparticles with a hypervalent iodine reagent, [Ph2I]BF4, resulted in the generation of Pd(ii)-aryl-oxo clusters, which were characterized as the crucial intermediate.

Palladium/Copper Cocatalyzed Coupling Reaction of Aroyl Hydrazides with Indoles

An unprecedented palladium/copper cocatalyzed coupling reaction of indoles with simple aroyl hydrazides has been developed under aerobic conditions. A range of aroyl hydrazides underwent palladium/copper cocatalyzed oxidative arylation with indoles open to air in a 1:1 mixture of dimethyl sulfoxide and nitromethane to give structurally diverse 2-arylindoles or 3-arylindoles in moderate to good yields. The reaction well tolerates a wide variety of functional groups such as alkoxy, halo, ester.

A Scalable Method for Regioselective 3-Acylation of 2-Substituted Indoles under Basic Conditions

Privileged structures such as 2-arylindoles are recurrent molecular scaffolds in bioactive molecules. We here present an operationally simple, high yielding and scalable method for regioselective 3-acylation of 2-substituted indoles under basic conditions