190182-60-6Relevant articles and documents
The discovery of carboline analogs as potent MAPKAP-K2 inhibitors
Wu, Jiang-Ping,Wang, Ji,Abeywardane, Asitha,Andersen, Denise,Emmanuel, Michel,Gautschi, Elda,Goldberg, Daniel R.,Kashem, Mohammed A.,Lukas, Susan,Mao, Wang,Martin, Leslie,Morwick, Tina,Moss, Neil,Pargellis, Christopher,Patel, Usha R.,Patnaude, Lori,Peet, Gregory W.,Skow, Donna,Snow, Roger J.,Ward, Yancey,Werneburg, Brian,White, Andre
, p. 4664 - 4669 (2008/02/13)
The discovery of a series of potent, carboline-based MK2 inhibitors is described. These compounds inhibit MK2 with IC50s as low as 10 nM, as measured in a DELFIA assay. An X-ray crystal structure reveals that they bind in a region near the p-lo