1903-69-1

Basic information

• Product Name: N-METHYLPIPERIDINE-4-CARBOXAMIDE
• Synonyms: N-Methyl-4-piperidinecarboxaMide
• CAS NO: 1903-69-1
• Molecular Formula: C₇H₁₄N₂O
• Molecular Weight: 142.2
• Mol File: 1903-69-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 123～125℃
• Boiling Point: 318.5°Cat760mmHg
• Flash Point: 149.6°C
• Appearance: /
• Density: 0.997g/cm³
• Vapor Pressure: 0.000361mmHg at 25°C
• Refractive Index: 1.462
• CAS DataBase Reference: N-METHYLPIPERIDINE-4-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHYLPIPERIDINE-4-CARBOXAMIDE(1903-69-1)
• EPA Substance Registry System: N-METHYLPIPERIDINE-4-CARBOXAMIDE(1903-69-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1903-69-1(Hazardous Substances Data)

Usage

General Description

N-METHYLPIPERIDINE-4-CARBOXAMIDE is a chemical compound with the molecular formula C8H15NO. It is a derivative of piperidine, a heterocyclic organic compound. N-METHYLPIPERIDINE-4-CARBOXAMIDE is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of dyes, rubber chemicals, and other fine chemicals. The compound is a white to off-white solid at room temperature and is stable under normal conditions. N-METHYLPIPERIDINE-4-CARBOXAMIDE is considered to be relatively non-toxic and non-hazardous, but proper safety measures should still be taken when handling and storing the compound.

InChI:InChI=1/C7H14N2O/c1-8-7(10)6-2-4-9-5-3-6/h6,9H,2-5H2,1H3,(H,8,10)

Upstream product

• 6843-37-4 N-methylisonicotinamide 
• 544696-01-7 tert-butyl 4-(methylcarbamoyl)piperidine-1-carboxylate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 

Downstream Products

• 126579-26-8 4-(N-Methylaminomethyl)piperidine 
• 1122471-60-6 C₂₅H₃₀F₃N₃O₆S 
• 1104382-08-2 1-methyl-6-(4-{3-[4-(N-methylaminocarbonyl)-piperidin-1-yl]-propoxy}-3-(trifluoromethyl)-phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile trifluoroacetate 
• 1400793-97-6 1-[4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzyl]-piperidine-4-carboxylic acid methylamide 

Relevant articles and documents

Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles

The potential of specific proteasome inhibitors to act as anti-cancer agents has attracted intensive investigations. The proteasome can be covalently inhibited by epoxyketone derivatives via a two-step reaction. Several computational approaches have been developed to mimic the covalent binding event. Compound 1 composed of a six-membered heterocyclic ring was designed by using covalent docking. With a possible different binding mode from the clinical compound Carfilzomib, it occupied the S5 pocket of 20S proteasome and showed favorable inhibitory activity. Subsequently optimization and evaluation were taken place. Among these compounds, 11h demonstrated extraordinary in vitro inhibitory activity and selectivity, and good in vivo proteasome inhibitory activity, a favorable pharmacokinetic profile and xenograft tumor inhibition. The possible binding pattern of compound 11h against proteasome was further fully explored via calculations, providing a theoretical basis for finding potent proteasome inhibitors.

PYRIDINE AND PYRIMIDINE BASED COMPOUNDS AS WNT SIGNALING PATHWAY INHIBITORS FOR THE TREATMENT OF CANCER

The present invention relates to pyridine and pyrimidine based compounds, pharmaceutical compositions comprising these compounds and their potential use as therapeutic agents for the treatment and / or prevention of cancer.

Facile Reduction of Pyridines with Nickel-Aluminum Alloy

Nickel-aluminum alloy in dilute base can be used to reduce a variety of pyridines, quinolines, and isoquinoline to the corresponding piperidines, 1,2,3,4-tetrahydroquinolines, and 1,2,3,4-tetrahydroisoquinoline in good yield.The reaction is simple to perform, and high temperatures, high pressures, or hydrogen atmospheres are not required.The reaction is accelerated by substituents in the 2-position and by electron-withdrawing groups in the 3- and 4-positions while electron-supplying groups in the 3- and 4-positions retard the reaction.The major product isolated from the reduction of 2-phenylpyridine was 2-cyclohexylpiperidine hydrochloride.With isoniazid (1) and iproniazid (4) the pyridine ring is hydrogenated before the hydrazine is cleaved.