19031-71-1

Basic information

• Product Name: (1-fluorobutyl)benzene
• Synonyms: (1-fluorobutyl)benzene
• CAS NO: 19031-71-1
• Molecular Weight: 152.212
• Mol File: 19031-71-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1-fluorobutyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (1-fluorobutyl)benzene(19031-71-1)
• EPA Substance Registry System: (1-fluorobutyl)benzene(19031-71-1)

Safety Data

• Hazardous Substances Data: 19031-71-1(Hazardous Substances Data)

Upstream product

• 103-82-2 phenylacetic acid 
• 7782-21-0 (RS)-2-phenylpentanoic acid 
• 614-14-2 1-Phenyl-1-butanol 

Relevant articles and documents

Insertion of Diazo Esters into C-F Bonds toward Diastereoselective One-Carbon Elongation of Benzylic Fluorides: Unprecedented BF3Catalysis with C-F Bond Cleavage and Re-formation

Selective transformation of C-F bonds remains a significant goal in organic chemistry, but C-F insertion of a one-carbon-atom unit has never been established. Herein we report the BF3-catalyzed formal insertion of diazo esters as one-carbon-atom sources into C-F bonds to accomplish one-carbon elongation of benzylic fluorides. A DFT calculation study revealed that the BF3 catalyst could contribute to both C-F bond cleavage and re-formation. This elongation provided α-fluoro-α,β-diaryl esters with a high level of diastereoselectivity. Various benzylic fluorides and diazo esters were applicable. The synthetic utility of this method was demonstrated by the synthesis of a fluoro analogue of a compound that is used as a transient receptor and potential canonical channel inhibitor.