190516-85-9

Basic information

• Product Name: 7-METHOXY-1H-4-QUINOLINONE
• Synonyms: 7-METHOXY-1H-4-QUINOLINONE
• CAS NO: 190516-85-9
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18
• Mol File: 190516-85-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 219-220 °C
• Boiling Point: 317.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.199±0.06 g/cm3(Predicted)
• PKA: 1.95±0.50(Predicted)
• CAS DataBase Reference: 7-METHOXY-1H-4-QUINOLINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHOXY-1H-4-QUINOLINONE(190516-85-9)
• EPA Substance Registry System: 7-METHOXY-1H-4-QUINOLINONE(190516-85-9)

Safety Data

• Hazardous Substances Data: 190516-85-9(Hazardous Substances Data)

Usage

Description

7-Methoxy-1H-4-quinolinone is a heterocyclic chemical compound that belongs to the class of quinolinone derivatives. It has a molecular formula of C10H9NO2 and a molecular weight of 175.18 g/mol. 7-METHOXY-1H-4-QUINOLINONE is characterized by a methoxy group attached to the 7th carbon of the quinolinone ring, which gives it unique structural and potential pharmacological properties.

Uses

Used in Pharmaceutical Synthesis:
7-Methoxy-1H-4-quinolinone is used as an intermediate in the synthesis of various pharmaceuticals and research chemicals. Its unique structure makes it a valuable building block in the development of new drugs.
Used in Organic Synthesis:
Due to its distinctive chemical properties, 7-Methoxy-1H-4-quinolinone is also used as a building block in organic synthesis, allowing for the creation of a wide range of chemical compounds.
Further Research:
While 7-Methoxy-1H-4-quinolinone has shown potential in various applications, more research is needed to fully understand its capabilities and properties. This will help in exploring additional uses and optimizing its role in pharmaceutical and chemical industries.

Upstream product

• 213699-52-6 5-[[(3-methoxyphenyl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
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• 3219-34-9 2-(N-Formyl-amido)-4-methoxy-acetophenon 
• 89691-67-8 1-(2-bromo-4-methoxyphenyl)ethanone 
• 77287-34-4 formamide 
• 879-56-1 7-Methoxy-2,3-dihydro-1H-quinolin-4-one 
• 766-85-8 3-methoxy-1-iodobenzene 
• 61999-50-6 N-(3-methoxyphenyl)azetidin-2-one 
• 56881-19-7 Diethyl 2-<(3-methoxyphenylamino)methylene>malonate 
• 71083-05-1 7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 
• 18096-70-3 3-(dimethylamino)-1-(4-methoxyphenyl)prop-2-en-1-one 
• 18096-70-3 3-dimethylamino-4'-methoxyacrylophenone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 68500-37-8 4-chloro-7-methoxyquinoline 
• 178984-56-0 7-(benzyloxy)-4-chloroquinoline 
• 181950-57-2 4-chloro-7-hydroxyquinoline 
• 178984-50-4 7-ethoxy-4-chloroquinoline 
• 178984-52-6 4-chloro-7-isopropoxyquinoline 

Relevant articles and documents

Design, synthesis, structure-activity relationships and mechanism of action of new quinoline derivatives as potential antitumor agents

A series of new quinoline derivatives was designed, synthesized and evaluated as potential antitumor agents. The results indicated that most compounds exhibited potent antiproliferative activity, and 7-(4-fluorobenzyloxy)–N-(2-(dimethylamino)- ethyl)quinolin-4-amine 10g was found to be the most potent antiproliferative agent against human tumor cell lines with an IC50 value of less than 1.0 μM. Preliminary structure-activity relationships analysis suggested that (1) the large and bulky alkoxy substituent in position-7 might be a beneficial pharmacophoric group for antiproliferative activity; (2) the amino side chain substituents in position-4 facilitated the antiproliferative activity of this class of compounds; and (3) the length of the alkylamino side chain moiety affected the antiproliferative potency, with two CH2 units being the most favorable. Further investigation of the mechanism of action of this class of compounds demonstrated that the representative compound 10g triggered p53/Bax-dependent colorectal cancer cell apoptosis by activating p53 transcriptional activity. Moreover, the results showed that compound 10g effectively inhibited tumor growth in a colorectal cancer xenograft model in nude mice. Thus, these quinoline derivatives might serve as candidates for the development of new antitumor drugs.

For antibacterial chlorine oxygen kui derivatives

The invention relates to an oxo-quinoline derivative with activity of resisting bacterial infection relevant diseases such as helicobacter pylori (Hp) infection disease. The invention specifically relates to a compound as shown in formula I in the specification, and a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R is selected from hydrogen, -C alkyl, -C alkenyl, -C alkynyl, or -C alkyl-phenyl, and the alkyl, alkenyl, alkynyl and phenyl can be randomly substituted by halogen, nitro, cyan, hydroxyl, -C alkoxy and phenyl; R is selected from hydrogen, -CONHR and -COOR, R and R are independently selected from -C alkyl and -C alkyl amino, and the amino is randomly substituted by one to two -C alkyls; R is selected from halogen, -C alkoxy, morpholinyl or piperazinyl.

Co(III)-Catalyzed Enaminone-Directed C-H Amidation for Quinolone Synthesis

We report herein the development of a Co(III)-catalyzed enaminone-directed C-H amidation method for synthetic access to quinolones, an important heterocyclic scaffold for diverse pharmaceutically active structures. The C-H coupling with dioxazolones and subsequent deacylation of an installed amide group allow consecutive C-N coupling generation of quinolones with wide-ranging compatible substituent patterns.