19064-68-7 Usage
Description
1-Chloro-4-methylphthalazine, with the CAS number 19064-68-7, is a light orange crystalline solid that serves as a valuable compound in the realm of organic synthesis. Its unique chemical structure and properties make it a versatile building block for the creation of various complex organic molecules.
Uses
Used in Organic Synthesis:
1-Chloro-4-methylphthalazine is used as a synthetic building block for the development of complex organic molecules. Its chemical properties, including the presence of a chlorine atom and a methyl group, allow for a wide range of reactions and functional group transformations, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
1-Chloro-4-methylphthalazine is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity enable the development of new drugs with improved efficacy and reduced side effects. The compound's versatility in organic synthesis allows for the creation of a diverse array of drug candidates, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
1-Chloro-4-methylphthalazine is also utilized as a key intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its chemical properties facilitate the development of novel active ingredients that can effectively control pests and weeds, leading to increased crop yields and improved agricultural productivity.
Used in Dye and Pigment Industry:
The light orange crystalline nature of 1-Chloro-4-methylphthalazine makes it a suitable candidate for use in the dye and pigment industry. Its unique color properties can be harnessed to create new dyes and pigments for various applications, including textiles, plastics, and printing inks.
Check Digit Verification of cas no
The CAS Registry Mumber 19064-68-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,0,6 and 4 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 19064-68:
(7*1)+(6*9)+(5*0)+(4*6)+(3*4)+(2*6)+(1*8)=117
117 % 10 = 7
So 19064-68-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H7ClN2/c1-6-7-4-2-3-5-8(7)9(10)12-11-6/h2-5H,1H3
19064-68-7Relevant articles and documents
Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition
Elmeligie, Salwa,Aboul-Magd, Asmaa M.,Lasheen, Deena S.,Ibrahim, Tamer M.,Abdelghany, Tamer M.,Khojah, Sohair M.,Abouzid, Khaled A. M.
, p. 1347 - 1367 (2019/07/29)
In the designed compounds, either a biarylamide or biarylurea moiety or an N-substituted piperazine motif was linked to position 1 of the phthalazine core. The anti-proliferative activity of the synthesised compounds revealed that eight compounds (6b, 6e, 7b, 13a, 13c, 16a, 16d and 17a) exhibited excellent broad spectrum cytotoxic activity in NCI 5-log dose assays against the full 60 cell panel with GI50 values ranging from 0.15 to 8.41 μM. Moreover, the enzymatic assessment of the synthesised compounds against VEGFR-2 tyrosine kinase showed the significant inhibitory activities of the biarylureas (12b, 12c and 13c) with IC50s of 4.4, 2.7 and 2.5 μM, respectively, and with 79.83, 72.58 and 71.6% inhibition of HUVEC at 10 μM, respectively. Additionally, compounds (7b, 13c and 16a) were found to induce cell cycle arrest at S phase boundary. Compound 7b triggered a concurrent increase in cleaved caspase-3 expression level, indicating the apoptotic-induced cell death.
ANTIMICROBIAL AGENTS
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Page/Page column 52, (2013/07/25)
The invention provides methods of treating a bacterial infection in a mammal comprising administering to the mammal a substituted bicyclic heteroaromatic ring compound of formula I: wherein two of X1 to X8 are N and the remaining of X1 to X8 are CH; or a pharmaceutically acceptable salt thereof, as well as novel compounds of formula I and salts thereof and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof.
