190659-59-7

Basic information

• Product Name: 5-chloro-3-methyl-benzo[b]thiophene-2-sulfonic acid amide
• Synonyms: 5-chloro-3-methyl-benzo[b]thiophene-2-sulfonic acid amide
• CAS NO: 190659-59-7
• Molecular Weight: 261.753
• Mol File: 190659-59-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-chloro-3-methyl-benzo[b]thiophene-2-sulfonic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3-methyl-benzo[b]thiophene-2-sulfonic acid amide(190659-59-7)
• EPA Substance Registry System: 5-chloro-3-methyl-benzo[b]thiophene-2-sulfonic acid amide(190659-59-7)

Safety Data

• Hazardous Substances Data: 190659-59-7(Hazardous Substances Data)

Upstream product

• 166964-33-6 5-chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride 

Relevant articles and documents

Synthesis and cytotoxic evaluation of substituted sulfonyl-n- hydroxyguanidine derivatives as potential antitumor agents

A series of sulfonyl-N-hydroxygnanidine derivatives was designed and synthesized for cytotoxic evaluation as potential anticancer agents on the basis of the lead compound LY-181984. Replacement of the ureido moiety of the lead compound with hydrexyguanidine provided a stable cytotoxic agent. The conformation of sulfonyl-N-hydroxyguanidine derivatives, such as N-(4- chlorophenyl-)-N-[(benzo[2,3]thiadiazol-4-yl)sulfonyl]-N-hydroxyguanidine (4g), investigated utilizing HMBC NMR, theoretical calculations, and X-ray crystallography, indicated stacking of the two aromatic rings. The derivatives were evaluated for in vitro cytoxicity against five human tumor cell lines, including HepG2, TSGH 8302, COLO 205, KB, and MOLT-4. The cytotoxic activities of the derived compounds against the human tumor cell lines were equal to or greater than that of the lead compound. N-(4- Chlorophenyl)-N'-[[3,5-dichloro-4-(4-nitrophenoxy)phenyl]sulfonyl].N- hydroxyguanidine (4n) and N-(4-chlorophenyl)-N'-[[3,5-dichloro4-(2-chloro-4- nitrophenoxy)phenyl]sulfonyl]-N-hydroxyguanidine (40) exhibited the greatest growth inhibition of solid tumor cell lines. Compound 40 was found to possess antitumor activity against murine K1735/M2 melanoma xenografts.