19068-33-8

Basic information

• Product Name: (R)-(+)-1-Amino-1-phenylpropaneHCl
• Synonyms: (R)-(+)-1-Amino-1-phenylpropaneHCl;(R)-(+)-1-Amino-1-phenylpropane hydrochloride;(R)-alpha-Ethylbenzenemethanamine hydrochloride
• CAS NO: 19068-33-8
• Molecular Formula: C₉H₁₃N*ClH
• Molecular Weight: 171.67
• Mol File: 19068-33-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 203.9 °C at 760 mmHg
• Flash Point: 85.1 °C
• Appearance: /
• Vapor Pressure: 0.272mmHg at 25°C
• CAS DataBase Reference: (R)-(+)-1-Amino-1-phenylpropaneHCl(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-1-Amino-1-phenylpropaneHCl(19068-33-8)
• EPA Substance Registry System: (R)-(+)-1-Amino-1-phenylpropaneHCl(19068-33-8)

Safety Data

• Hazardous Substances Data: 19068-33-8(Hazardous Substances Data)

Usage

General Description

(R)-(+)-1-Amino-1-phenylpropaneHCl, also known as D-Methamphetamine hydrochloride, is a psychoactive and stimulant drug that is commonly used as a recreational substance. It is classified as a Schedule II controlled substance in the United States due to its potential for abuse and addiction. When used, it produces feelings of euphoria, increased energy, and increased alertness. It also has the potential to cause harmful side effects such as increased heart rate, elevated blood pressure, and potential overdose. The chemical structure of this compound consists of a phenyl group attached to a propylamine chain, and the hydrochloride salt form is the most common form used for recreational purposes.

InChI:InChI=1/C9H13N.ClH/c1-2-9(10)8-6-4-3-5-7-8;/h3-7,9H,2,10H2,1H3;1H/t9-;/m1./s1

Upstream product

• 74-96-4 ethyl bromide 
• 7699-79-8 benzhydrylidene-benzyl-amine 
• 196929-90-5 (R_S)-2-methyl-N-((R)-1-phenylpropyl)propane-2-sulfinamide 
• 925-90-6 ethylmagnesium bromide 
• 186249-76-3 (R,E)-2-methyl-N-(phenylmethylene)-2-propanesulfinamide 
• 221375-47-9 (R)-(-)-N-(propylidene)-2-methylpropane-2-sulfinamide 
• 100-52-7 benzaldehyde 
• 622840-47-5 (1R,1'R,2R,4R,S_S)-N-(1'-phenylpropyl)-2-(2-trimethylsilyloxy-4-methylcyclohexyl)propane-2-sulfinamide 
• 106651-16-5 N-(1-phenylpropyl)-diphenylphosphinamide 
• 911372-50-4 (R_S)-2-methyl-N-(1-phenylpropylidene)propane-2-sulfinamide 
• 93-55-0 1-phenyl-propan-1-one 
• 622840-45-3 (1R,2R,4R,S_S)-N-[(1E)-benzylidene]-2-(2-trimethylsilyloxy-4-methylcyclohexyl)propane-2-sulfinamide 
• 61357-38-8 propiophenone-imine; hydrochloride 
• 108-86-1 bromobenzene 

Downstream Products

• 196929-90-5 (R_S)-2-methyl-N-((R)-1-phenylpropyl)propane-2-sulfinamide 
• 2698-79-5 (R)-N-(1-phenylpropyl)acetamide 

Relevant articles and documents

Rhodium-catalyzed asymmetric hydrogenation of unprotected NH imines assisted by a thiourea

Asymmetric hydrogenation of unprotected NH imines catalyzed by rhodium/bis(phosphine)-thiourea provided chiral amines with up to 97% yield and 95% ee. 1HNMR studies, coupled with control experiments, implied that catalytic chloride-bound intermediates were involved in the mechanism through a dual hydrogen-bonding interaction. Deuteration experiments proved that the hydrogenation proceeded through a pathway consistent with an imine.

One-pot synthesis of chiral nonracemic amines

One-pot five-component reactions of oxathiazolidine-S-oxides with mesitylmagnesium bromide, lithium bis(trimethylsilyl)amide, aldehydes and Grignard reagents afford chiral nonracemic amines or sulfinamides in good yields and high stereoselectivities.

Enantioselective hydrogenation of N-H imines

(Figure Presented) N-H ketoimines 3a-3v are readily prepared in high yield via organometallic addition to nitriles and isolated as corresponding bench-stable hydrochloride salts. Homogeneous asymmetric hydrogenation of unprotected N-H ketoimines 3a-3v usi