190966-70-2

Basic information

• Product Name: 2-(4-Fluoro-2-methyl-phenoxy)-5-nitro-thiophene
• Synonyms: 2-(4-Fluoro-2-methyl-phenoxy)-5-nitro-thiophene
• CAS NO: 190966-70-2
• Molecular Weight: 253.254
• Mol File: 190966-70-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-Fluoro-2-methyl-phenoxy)-5-nitro-thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Fluoro-2-methyl-phenoxy)-5-nitro-thiophene(190966-70-2)
• EPA Substance Registry System: 2-(4-Fluoro-2-methyl-phenoxy)-5-nitro-thiophene(190966-70-2)

Safety Data

• Hazardous Substances Data: 190966-70-2(Hazardous Substances Data)

Upstream product

• 13195-50-1 2-bromo-5-nitrothiophene 
• 452-72-2 4-fluoro-2-methylphenol 

Downstream Products

• 190967-03-4 N-[5-(4-Fluoro-2-methyl-phenoxy)-thiophen-2-yl]-acetamide 

Relevant articles and documents

N-(5-Substituted) thiophene-2-alkylsulfonamides as potent inhibitors of 5-lipoxygenase

Compound 4k N-[5-(4-fluoro)phenoxythien-2-yl]methanesulfonamide is representative of a new class of potent inhibitors of 5-lipoxygenase (5-LO). These versatile compounds exhibit dose-dependent inhibition of 5-LO with IC50s ranging from 20-100 nM in the rat basophilic leukemia (RBL-1) cell homogenate assay and submicromolar IC50s in both the RBL-1 and human peripheral blood leukocyte (PBL) whole cell assays. Compound 4k also showed significant anti-inflammatory activity in the adjuvant arthritic rat at an oral dose of 3 mg/kg.