19097-44-0

Basic information

• Product Name: 4-IODOBUTYL BENZOATE
• Synonyms: 4-IODOBUTYL BENZOATE
• CAS NO: 19097-44-0
• Molecular Formula: C₁₁H₁₃IO₂
• Molecular Weight: 304.12
• Mol File: 19097-44-0.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 330.4°C at 760 mmHg
• Flash Point: 153.6°C
• Appearance: /
• Density: 1.554g/cm³
• Vapor Pressure: 0.000167mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: 4-IODOBUTYL BENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODOBUTYL BENZOATE(19097-44-0)
• EPA Substance Registry System: 4-IODOBUTYL BENZOATE(19097-44-0)

Safety Data

• Hazardous Substances Data: 19097-44-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H13IO2/c12-8-4-5-9-14-11(13)10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2

Upstream product

• 109-99-9 tetrahydrofuran 
• 98-88-4 benzoyl chloride 
• 93-97-0 benzoic acid anhydride 
• 32651-37-9 4-benzoyloxybutan-1-ol 
• 532-32-1 sodium benzoate 

Downstream Products

• 161421-55-2 1-(4-benzoyloxybutyl)-4,5-dichloropyridazin-6-one 
• 187410-90-8 1-(benzoyloxy)-5-methylideneheptan-6-one 
• 272120-82-8 7-(4-benzoyloxybutyl)-4-chloro-5-cyano-2-methyl-7H-pyrrolo[2,3-c]pyridazin-3(2H)-one 
• 272120-83-9 7-(4-benzoyloxybutyl)-4-chloro-5-cyano-2-ethyl-7H-pyrrolo[2,3-c]pyridazin-3(2H)-one 
• 272120-84-0 7-(4-benzoyloxybutyl)-4-chloro-5-cyano-2-propyl-7H-pyrrolo[2,3-c]pyridazin-3(2H)-one 
• 854760-11-5 benzoic acid 5-oxo-hept-6-enyl ester 
• 161421-58-5 4-amino-1-(4-benzoyloxybutyl)-5-chloropyridazin-6-one 
• 161421-61-0 1-(4-benzoyloxybutyl)-5-chloro-4-methylaminopyridazin-6-one 
• 161421-71-2 1-(4-benzoyloxybutyl)-4,5-dimethoxypyridazin-6-one 
• 161421-67-6 1-(4-benzoyloxybutyl)-5-chloro-4-hydrazinopyridazin-6-one 
• 161421-56-3 4-azido-1-(4-benzoyloxybutyl)-5-chloropyridazin-6-one 
• 161421-64-3 1-(4-benzoyloxybutyl)-5-chloro-4-(2-chloroacetamido)pyridazin-6-one 
• 851118-44-0 C₁₂H₁₃NO₃ 
• 1137726-22-7 4-[4-(benzoyloxy)butyl]benzenecarbonitrile 

Relevant articles and documents

Tetrahydrofuran ring opening with acid chlorides catalyzed by samarium triiodides

SmI3 acts as Lewis-acid catalysts in tetrahydrofuran ring opening reactions with acid chlorides under mild conditions.

Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors

Macrocycles have attracted significant attention in drug discovery recently. In fact, a few de novo designed macrocyclic kinase inhibitors are currently in clinical trials with good potency and selectivity for their intended target. In this study, we successfully engaged a structure-based drug design approach to discover macrocyclic pyrimidines as potent Mer tyrosine kinase (MerTK)-specific inhibitors. An enzyme-linked immunosorbent assay (ELISA) in 384-well format was employed to evaluate the inhibitory activity of macrocycles in a cell-based assay assessing tyrosine phosphorylation of MerTK. Through structure–activity relationship (SAR) studies, analogue 11 [UNC2541; (S)-7-amino-N-(4-fluorobenzyl)-8-oxo-2,9,16-triaza-1(2,4)-pyrimidinacyclohexadecaphane-1-carboxamide] was identified as a potent and MerTK-specific inhibitor that exhibits sub-micromolar inhibitory activity in the cell-based ELISA. In addition, an X-ray structure of MerTK protein in complex with 11 was resolved to show that these macrocycles bind in the MerTK ATP pocket.

The backbone N-(4-azidobutyl) linker for the preparation of peptide chimera

A robust synthetic strategy for the introduction of the N-(4-azidobutyl) linker into peptides using standard SPPS techniques is described. Based on the example of Cilengitide it is shown that the N-(4-azidobutyl) group exerts similar conformational restra

Nucleotide and oligonucleotide prodrugs

The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV