191112-67-1

Basic information

• Product Name: tert-butyl 2-hydroxy-5-methylphenylcarbamate
• Synonyms: tert-butyl 2-hydroxy-5-methylphenylcarbamate
• CAS NO: 191112-67-1
• Molecular Formula: C₁₂H₁₇NO₃
• Molecular Weight: 223.26828
• Mol File: 191112-67-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 2-hydroxy-5-methylphenylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-hydroxy-5-methylphenylcarbamate(191112-67-1)
• EPA Substance Registry System: tert-butyl 2-hydroxy-5-methylphenylcarbamate(191112-67-1)

Safety Data

• Hazardous Substances Data: 191112-67-1(Hazardous Substances Data)

Upstream product

• 1095280-73-1 N-Boc-N-(3-methylphenyl)-O-(4-nitrobenzoyl)hydroxylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 95-84-1 3-amino-4-hydroxytoluene 

Downstream Products

• 95-84-1 3-amino-4-hydroxytoluene 
• 457098-39-4 [2-(3-dimethylamino-propoxy)-5-methyl-phenyl]-carbamic acid tert-butyl ester 
• 1140039-74-2 3-(2-tert-Butoxycarbonylamino-4-methyl-phenoxymethyl)-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester 
• 457098-91-8 [5-Methyl-2-(1,2,3,4-tetrahydro-quinolin-3-ylmethoxy)-phenyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Continued Exploration of Trifunctional Alkyl 4-Chloro-2-diazo-3-oxobutanoates: Streamlined Entry into [1,2,3]Triazolo[5,1- c ][1,4]benzoxazines and [1,2,3]Triazolo[5,1- c ][1,4]benzoxazepines

Further exploration of the trifunctional character of previously introduced alkyl 4-chloro-2-diazo-3-oxobutanoates in reactions with N -protected substituted o -aminophenols followed by deprotection provided a convenient entry into [1,2,3]triazolo[5,1- c ][1,4]benzoxazines, which are of high medicinal importance, as documented in the literature. The same approach applied to N -protected substituted o -(aminomethyl)phenols afforded [1,2,3]triazolo[5,1- c ][1,4]benzoxazepines, which are practically unexplored compounds from a medicinal chemistry perspective. The syntheses start with S N 2-type alkylation of the phenol. Removal of the protecting group triggers imine formation followed by Wolff 1,2,3-triazole synthesis.

An Expedient Synthesis of 2-Aryl-1,4-benzoxazin-3-ones via Tandem Anionic Cyclisation/Alkylation Reactions of N -Boc- O -benzyl-2-aminophenols

A one-pot, tandem anionic cyclization/alkylation reaction of N-Boc-O-benzylated-2-aminophenols to give 2-aryl-1,4-benzoxazin-3-ones is described. The Boc protecting group plays a crucial role in the process, as the tert-butoxide liberated in the cyclisati

Rearrangement of differentially protected N-arylhydroxylamines

The rearrangement of a series of N,O-difunctionalised N-arylhydroxylamines to generate protected 2-aminophenols has been investigated. N-Boc-N-Aryl-O- acylhydroxylamines are stable, isolable compounds which rearrange smoothly at temperatures between 110 and 140°C. The corresponding N-Boc-N-aryl-O- sulfonylhydroxylamines were not isolated and rearrange to 1,2-difunctionalised aminophenols at room temperature in excellent yield. Deprotection of either the N- or O-substituents under standard conditions allows for further synthetic manipulation of either the aniline or phenol functionality. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.